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IL4

interleukin 4

IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene Name: interleukin 4
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL4, B cell growth factor 1, B-cell stimulatory factor 1, B_cell stimulatory factor 1, BCGF1, BSF-1, Binetrakin, BCGF-1, Interleukin 4, Interleukin-4, Pitrakinra, BSF1, IL-4
Target Sequences: NM_000589 NP_000580.1 P05112

Publications (3)

1
Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Gong G, Shao L, Wang Y, Chen CY, Huang D, Yao S, Zhan X, Sicard H, Wang R, Chen ZW. Blood. 2009 113:837-45. [PubMed:18981295] [PMC:PMC2630269] Related Antibodies: LS-C41019.
2
Modulation of Binge-like Ethanol Consumption by IL-10 Signaling in the Basolateral Amygdala. S Alex Marshall, Kyle H McKnight, Allyson K Blose, Donald T Lysle, Todd E Thiele. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2017 June;12:249-259. [Full Text Article] [PubMed:27640210] [PMC:PMC5357210] Related Antibodies: LS-C745952.
3
Delivery of Interleukin-4-Encoding Lentivirus Using Multiple-Channel Bridges Enhances Nerve Regeneration. S Ahmed Ali, John E Hanks, Aaron W Stebbins, Osama Alkhalili, Samantha T Cohen, Jessica Y Chen, Dominique R Smith, Courtney M Dumont, Lonnie D Shea, Norman D Hogikyan, Eva L Feldman, Michael J Brenner. The Laryngoscope. 2020 December;130:2802-2810. [Full Text Article] [PubMed:32220076] [PMC:PMC7893531] Related Antibodies: LS-C408858.

☰ Filters
Products
Proteins (74)
Over-Expression Lysate (2)
Recombinant (72)
IL4 (74)
Animal-free (2)
No (74)
10His-B2M, N-terminus + Myc, C-terminus (1)
6His, C-terminus (5)
6His, N-terminus (3)
6His-SUMO, N-terminus (1)
Fc, C-terminus (1)
GST (1)
GST, N-terminus (1)
His (9)
His, C-Terminal (1)
His, N-Terminal (5)
His,C-terminus (1)
His-GST (2)
His-T7 (3)
Human IgG1 Fc, C-terminus (1)
Human Mutant IgG1 Fc (1)
Mouse Mutant IgG2a Fc (1)
Myc-DDK (Flag) (3)
Bovine (2)
Chicken (1)
Crab-eating macaque (1)
Dog (2)
Human (38)
Mouse (16)
Pig (4)
Rabbit (2)
Rat (4)
Rhesus monkey (1)
Sheep (2)
293F Cells (2)
293T Cells (1)
CHO Cells (7)
E. coli (36)
HEK 293 Cells (6)
Human (4)
Human Cells (2)
Mammalian Cells (5)
Wheat Germ Extract (2)
Yeast (4)
Purified (24)
Low endotoxin level (38)
Biologically active (25)
Animal-free (2)
IL4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
1 mg/$1,973; 100 µg/$679; 20 µg/$429
Select
CHO Cells
Human IgG1 Fc, C-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
43 kDa (predicted)
50 µg/$428; 10 µg/$337
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15 kDa (SDS-PAGE)
50 µg/$342; 10 µg/$286; 1 mg/$1,612
IL4 Protein
Select
E. coli
None
Biologically active
14.9 kDa
5 µg/$267; 20 µg/$351; 100 µg/$874; 250 µg/$1,382; 1 mg/$2,839; 500 µg/$1,917
IL4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
50 µg/$487; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987
IL4 Protein - Purified recombinant protein IL4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
14.9 kDa
20 µg/$1,107
IL4 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Yeast
6His, N-terminus
14.6 kDa
100 µg/$679; 20 µg/$429; 1 mg/$1,973
Select
HEK 293 Cells
His
15.5 kDa
10 µg/$323; 50 µg/$702; 100 µg/$1,043
IL4 Protein - Recombinant  Interleukin 4 By SDS-PAGE
Select
E. coli
His, N-Terminal
16.2 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15 kDa (SDS-PAGE)
50 µg/$551; 10 µg/$304; 1 mg/$3,157
IL4 Protein
Select
E. coli
None
Biologically active
13.5 kDa
5 µg/$282; 100 µg/$1,030; 500 µg/$1,891
IL4 Protein - Recombinant Rabbit interleukin-4 detected using Goat anti Rabbit interleukin-4 as the capture reagent and Goat anti Rabbit interleukin-4:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
14.2 kDa
5 µg/$390
IL4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
13.2 kDa
100 µg/$494
IL4 Protein
Select
E. coli
None
Less than 0.1 EU/µg protein (determined by LAL method).
15.1 kDa
50 µg/$677
IL4 Protein
Select
E. coli
His, N-Terminal
14.9 kDa
50 µg/$419
IL4 Protein - Recombinant Human Interleukin-4/IL-4 Protein-Elabscience
Select
Human
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
14.97 kDa
10 µg/$281; 50 µg/$389
IL4 Protein - Recombinant Human IL-4 (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
41.9 kDa
10 µg/$327; 50 µg/$574
Select
E. coli
His
16.9 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
IL4 Protein - 12.5% SDS-PAGE of human IL4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
42.46 kDa
2 µg/$439
IL4 Protein - Recombinant  Interleukin 4 By SDS-PAGE
Select
E. coli
His-T7
16.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Select
HEK 293 Cells
His
16.6 kDa
10 µg/$343; 50 µg/$662; 100 µg/$995
IL4 Protein
Select
Yeast
His
16.96 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
Select
IL4 Protein - Biological Activity IL-4, Human stimulates cell proliferation of R&D TF-1 cells. The ED 50 for this effect is typically 0.05-0.25ng/mL.
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$278; 1 mg/$1,612
IL4 Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
17 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Viewing 1-25 of 74 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).