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IL36B

interleukin 36, beta

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

Gene Name: interleukin 36, beta
Family/Subfamily: IL-1 , not assigned-IL-1
Synonyms: IL36B, FIL1, FIL1 eta, FILI-(ETA), IL-1 eta, IL-1F8, Interleukin 1, eta, Interleukin-1 eta, IL1F8, Interleukin 36, beta, Interleukin-1 family member 8, Interleukin-1 Superfamily e, Family of interleukin 1-eta, FIL1H, Interleukin-1 homolog 2, FIL1-(ETA), IL-1F8 (FIL1-eta), IL-1H2, IL1-ETA, IL1H2, Interleukin-36 beta
Target Sequences: NM_014438 NP_055253.2 Q9NZH7

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ELISA Kits (10)
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IL36B (10)
Human (6)
Mouse (2)
Rat (2)
96-Well Strip Plate (10)
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Cell Culture Supernatants (3)
Cell Lysates (2)
Plasma (9)
Serum (9)
Tissue Homogenates (4)
IL36B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
IL36B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
IL36B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IL36B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IL36B ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$685
IL36B ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
1.37 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$968
IL36B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IL36B ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IL36B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$893
IL36B ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$958
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).