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IL36B
interleukin 36, beta
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
| Gene Name: | interleukin 36, beta |
| Family/Subfamily: | IL-1 , not assigned-IL-1 |
| Synonyms: | IL36B, FIL1, FIL1 eta, FILI-(ETA), IL-1 eta, IL-1F8, Interleukin 1, eta, Interleukin-1 eta, IL1F8, Interleukin 36, beta, Interleukin-1 family member 8, Interleukin-1 Superfamily e, Family of interleukin 1-eta, FIL1H, Interleukin-1 homolog 2, FIL1-(ETA), IL-1F8 (FIL1-eta), IL-1H2, IL1-ETA, IL1H2, Interleukin-36 beta |
| Target Sequences: | NM_014438 NP_055253.2 Q9NZH7 |
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