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IL31RA

interleukin 31 receptor A

IL31RA belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene Name: interleukin 31 receptor A
Synonyms: IL31RA, CRL, CRL3, Cytokine receptor-like 3, GLM-R, GPL, IL-31R subunit alpha, IL-31R-alpha, IL-31RA, Interleukin 31 receptor A, GLMR, HGLM-R, IL-31 receptor subunit alpha, PLCA2, ZcytoR17, Class I cytokine receptor, gp130-like monocyte receptor, gp130-like receptor, PRO21384
Target Sequences: NM_139017 NP_620586.3 Q8NI17

Publications (1)

1
Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis. Ai Kuzumi, Ayumi Yoshizaki, Kazuki M Matsuda, Hirohito Kotani, Yuta Norimatsu, Maiko Fukayama, Satoshi Ebata, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Yoshihide Asano, Kyojiro Morikawa, Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori, Shinichi Sato. Nature communications. 2021 Oct;12:5947. [Full Text Article] [PubMed:34642338] [PMC:PMC8511151]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).