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2 Shaker Rd Suites
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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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IL27RA
interleukin 27 receptor, alpha
Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-g and lymphotoxin-b that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-g and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
| Gene Name: | interleukin 27 receptor, alpha |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL27RA, CRL1, Cytokine receptor-like 1, IL-27RA, IL27R, IL-27 receptor subunit alpha, IL-27R, IL-27R subunit alpha, TCCR, WSX-1, WSX1, Class I cytokine receptor, IL-27R-alpha, Interleukin 27 receptor, alpha, Zcytor1 |
| Target Sequences: | NM_004843 NP_004834.1 Q6UWB1 |
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