IL27

interleukin 27

Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II. IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication.

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Products

Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

IL27 (14)

Publications

No (14)

Tag

6His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His, C-Terminal (1)

Human IgG1 Fc (2)

Human Mutant IgG1 Fc (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Mouse (5)

Rat (1)

Source

293T Cells (1)

CHO Cells (4)

E. coli (2)

HEK 293 Cells (3)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (7)

Biologically Active

Biologically active (5)

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Human IL27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88418

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.3 kDa

Price:

20 µg/$150

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Human IL27 Protein (Recombinant Human Mutant IgG1 Fc) (aa21-229) - LS-G4084

Source:

CHO Cells

Tag:

Human Mutant IgG1 Fc

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

50 µg/$491

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Human IL27 Protein (Recombinant) - LS-G133802

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

47.8 kDa

Price:

10 µg/$349; 2 µg/$268

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Mouse IL27 Protein (Recombinant 6His, C-terminus) (Tyr19-Pro228) - LS-G140794

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49 kDa

Price:

10 µg/$339; 50 µg/$633

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Human IL27 Protein (Recombinant GST) (Full Length) - LS-G37089

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IL27 Protein (Recombinant GST, N-terminus) (aa177-243) - LS-G63843

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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IL27 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102323

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.3 kDa

Price:

100 µg/$494

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Human IL27 Protein (Recombinant Human IgG1 Fc) (aa21-229) - LS-G4030

Source:

CHO Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

50 µg/$480

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Mouse IL27 Protein (Recombinant Human IgG1 Fc) (aa1-228) - LS-G4138

Source:

CHO Cells

Tag:

Human IgG1 Fc

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

50 µg/$491

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Mouse IL27 Protein (Recombinant His, C-Terminal) (Tyr19-Pro228) - LS-G40368

Source:

Human Cells

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49kD

Price:

10 µg/$343; 50 µg/$651; 500 µg/$2,403; 1 mg/$3,431

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Human IL27 Protein (Recombinant) - LS-G137840

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The total predicted molecular weight is 50 kD. The non-reduced and the DTT-reduced proteins migrate as one band at approximately 60 kD by SDS-PAGE.

Price:

10 µg/$352; 25 µg/$535

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Mouse IL27 Protein (Recombinant) - LS-G137841

Source:

HEK 293 Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg (determined by LAL method).

Molecular Weight:

The total predicted molecular weight is 49 kD. The non-reduced and the DTT-reduced proteins migrate as one band at approximately 55 kD by SDS-PAGE.

Price:

10 µg/$398; 25 µg/$512; 100 µg/$1,363; 500 µg/$4,061

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Rat IL27 Protein (Recombinant His) (aa32-234) - LS-G12091

Source:

E. coli

Tag:

His

Molecular Weight:

24.5 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Mouse IL27 Protein (Recombinant His) (aa29-234) - LS-G12094

Source:

E. coli

Tag:

His

Molecular Weight:

24.8 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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