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IL23A / IL-23 p19
interleukin 23, alpha subunit p19
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
| Gene Name: | interleukin 23, alpha subunit p19 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL23A, IL-23 subunit alpha, IL-23A, Interleukin 23 p19 subunit, Interleukin-23 subunit alpha, IL23P19, Interleukin-23 subunit p19, p19, SGRF, IL-23, IL-23 p19, IL-23-A, IL-23p19 |
| Target Sequences: | NM_016584 NP_057668.1 Q9NPF7 |
Publications (4)
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