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IL21

interleukin 21

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

Gene Name: interleukin 21
Family/Subfamily: Interleukin
Synonyms: IL21, Interleukin 21, Interleukin-21, Interleukin-21 isoform, Za11, IL-21
Target Sequences: NM_021803 NP_068575.1 Q9HBE4

Publications (3)

1
Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients. Maehara T, Moriyama M, Hayashida JN, Tanaka A, Shinozaki S, Kubo Y, Matsumura K, Nakamura S. Clinical and experimental immunology. 2012 169:89-99. (IHC; Human) [Full Text Article] [PubMed:22774983] [PMC:PMC3406368] Related Antibodies: LS-B1364.
2
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Michael P Crawford, Sushmita Sinha, Pranav S Renavikar, Nicholas Borcherding, Nitin J Karandikar. Proceedings of the National Academy of Sciences of the United States of America. 2020 August;117:19408-19414. [Full Text Article] [PubMed:32719138] [PMC:PMC7430972] Related Antibodies: LS-C104584.
3
Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. Maehara T, Moriyama M, Nakashima H, Miyake K, Hayashida JN, Tanaka A, Shinozaki S, Kubo Y, Nakamura S. Annals of the rheumatic diseases. 2012 Dec;71:2011-19. [Full Text Article] [PubMed:22753386] Related Antibodies: LS-B1364.

☰ Filters
Products
Proteins (35)
Over-Expression Lysate (2)
Recombinant (33)
IL21 (35)
Animal-free (1)
No (35)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
His,C-terminus (1)
His-GST (2)
Human Mutant IgG1 Fc (1)
Human Mutant IgG4 Fc, N-terminus (1)
Mouse IgG2a Fc, N-terminus (1)
Mouse Mutant IgG2a Fc (1)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Human (20)
Mouse (12)
293T Cells (1)
CHO Cells (3)
E. coli (23)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Yeast (2)
Purified (15)
Low endotoxin level (23)
Biologically active (14)
Animal-free (2)
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
50 µg/$587; 10 µg/$337
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15.4 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.4 kDa
10 µg/$317; 50 µg/$524
IL21 Protein - Recombinant Bovine interleukin-21 detected using Rabbit anti Bovine interleukin-21 as the capture reagent and Rabbit anti Bovine interleukin-21:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
15.1 kDa
5 µg/$390
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
IL21 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
14.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
IL21 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
18.5 kDa
20 µg/$150
Select
E. coli
None
15.6 kDa
100 µg/$1,129; 20 µg/$432
IL21 Protein - Recombinant Interleukin 21 By SDS-PAGE
Select
E. coli
His-GST
47.5 kDa
50 µg/$470; 10 µg/$285; 200 µg/$937; 100 µg/$750; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
IL21 Protein - Recombinant Interleukin 21 By SDS-PAGE
Select
E. coli
His-GST
47.6 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
IL21 Protein - 12.5% SDS-PAGE of human IL21 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
45.1 kDa
2 µg/$439
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15.1 kDa (SDS-PAGE)
50 µg/$483; 10 µg/$300; 1 mg/$2,976
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
14.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
IL21 Protein - Human IL-21 induced-production of IFN? by NK-92 cells.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 133 amino acid recombinant protein has a predicted molecular mass of approximately 15.5 kD. The DTT-reduced and non-reduced protein migrate at approximately 16 kD by SDS-PAGE. The N-terminal amino acid is Glutamine.
10 µg/$352; 25 µg/$474; 100 µg/$1,177; 500 µg/$2,596
IL21 Protein - CTLL-2 cell proliferation induced by mouse IL-21.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 122 amino acid recombinant protein has a predicted molecular mass of approximately 14.2 kD. The DTT-reduced and non-reduced proteins migrate at approximately 20 kD by SDS-PAGE. The N-terminal amino acid is Pro.
10 µg/$352; 25 µg/$478; 100 µg/$1,078
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.6 kDa
10 µg/$317; 50 µg/$524
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
14.4 kDa
10 µg/$317; 50 µg/$524
IL21 Protein - Recombinant Dog interleukin-21 detected using Rabbit anti Dog interleukin-21 as the capture reagent and Rabbit anti Dog interleukin-21:Biotin as the detection reagent followed by Streptavidin:HRP.
Select
Yeast
None
14.9 kDa
5 µg/$390
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
15.0 kDa
10 µg/$369; 2 µg/$281
Select
HEK 293 Cells
Mouse IgG2a Fc, N-terminus
Less than 5.0 EU/mg protein (determined by LAL method).
~45 kDa (SDS-PAGE)
50 µg/$470
Select
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~18 kDa (SDS-PAGE)
10 µg/$358
Select
E. coli
None
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~17 kDa (SDS-PAGE)
10 µg/$372; 50 µg/$748
Select
CHO Cells
Human Mutant IgG4 Fc, N-terminus
Less than 5.0 EU/mg protein (determined by LAL method).
~42 kDa (SDS-PAGE)
50 µg/$470
Viewing 1-25 of 35 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).