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IL1RL2
interleukin 1 receptor-like 2
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
| Gene Name: | interleukin 1 receptor-like 2 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL1RL2, IL-1Rrp2, IL1R-rp2, IL1RRP2, Interleukin 1 receptor-like 2, Interleukin-1 receptor-like 2, IL-36R |
| Target Sequences: | NM_003854 NP_003845.2 Q9HB29 |
Publications (1)
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