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IL1R1

interleukin 1 receptor, type I

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Gene Name: interleukin 1 receptor, type I
Family/Subfamily: Interleukin
Synonyms: IL1R1, Antigen CD121a, D2S1473, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1R, IL1RA, IL1RT1, Interleukin receptor 1, Interleukin-1 receptor alpha, Interleukin-1 receptor type 1, CD121A, CD121a antigen, Interleukin 1 receptor, type I, Interleukin-1 receptor type I, Interleukin-1 type i receptor, p80
Target Sequences: NM_000877 NP_000868.1 P14778

Publications (2)

1
IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Suzuki M, Hashizume M, Yoshida H, Shiina M, Mihara M. Cytokine. 2010 51:178-83. (WB) [PubMed:20403707]
2
The role of interleukin-1ß in human trophoblast motility. Prutsch N, Fock V, Haslinger P, Haider S, Fiala C, Pollheimer J, Knöfler M. Placenta. 2012 33:696-703. (ELISA; Human) [Full Text Article] [PubMed:22710193] Related Antibodies: LS-B2859.

☰ Filters
Products
Proteins (30)
Over-Expression Lysate (2)
Recombinant (28)
IL1R1 (30)
Product Group
Coronavirus Antibodies Proteins cDNAs (30)
Cytokine Release Syndrome Proteins (30)
No (30)
10His-SUMO, N-terminus + Myc, C-terminus (1)
6His, C-terminus (2)
Fc (2)
Fc, C-terminus (4)
GST, N-terminus (1)
His (8)
His, N-Terminal (4)
His,C-terminus (2)
His-Fc (1)
His-T7 (1)
Human IgG1 Fc (1)
Myc-DDK (Flag) (2)
Human (15)
Mouse (6)
Rat (8)
293T Cells (1)
E. coli (12)
HEK 293 Cells (3)
Human Cells (9)
Mammalian Cells (4)
Wheat Germ Extract (1)
Purified (10)
Low endotoxin level (15)
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~80kDa (SDS-PAGE)
50 µg/$393
IL1R1 Protein
Select
E. coli
His-T7
41.1 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
IL1R1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
65.4 kDa
100 µg/$494
IL1R1 Protein - Active Interleukin 1 Receptor Type I (IL1R1) by WB
Select
E. coli
His, N-Terminal
17kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
IL1R1 Protein - Active Interleukin 1 Receptor Type I (IL1R1) by WB
Select
E. coli
His, N-Terminal
13kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
IL1R1 Protein - Active Interleukin 1 Receptor Type I (IL1R1) by WB
Select
E. coli
His, N-Terminal
21kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64.0 kDa
10 µg/$248; 50 µg/$317
IL1R1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
IL1R1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
100 µg/$1,801; 20 µg/$1,247
IL1R1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
65.4 kDa
20 µg/$150
Select
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
64.6 kDa
100 µg/$721
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
64.3 kDa
100 µg/$600
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
37.7 kDa
100 µg/$839; 1 mg/$4,452
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
36.8 kDa
100 µg/$721
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
63 kDa
100 µg/$721
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.7 kDa
100 µg/$721
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.9 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.0 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.1 kDa
10 µg/$281; 50 µg/$389
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
62.9kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
64kD
10 µg/$248; 50 µg/$321; 500 µg/$725; 1 mg/$1,113
IL1R1 Protein - Active Interleukin 1 Receptor Type I (IL1R1) by WB
Select
E. coli
His, N-Terminal
14kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
IL1R1 Protein - Recombinant Interleukin 1 Receptor Type I By SDS-PAGE
Select
E. coli
His
12.1 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
E. coli
His
13.0 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
Viewing 1-25 of 30 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).