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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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IL18BP
interleukin 18 binding protein
IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Gene Name: | interleukin 18 binding protein |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL18BP, IL18BPa, Interleukin-18-binding protein, Interleukin 18 binding protein, Tadekinig-alfa, IL-18BP |
| Target Sequences: | NM_173042 NP_766630.2 O95998 |
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