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IL17A
interleukin 17A
IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
| Gene Name: | interleukin 17A |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL17A, CTLA-8, CTLA8, Interleukin-17A, Interleukin 17A, IL-17, IL-17A, IL17 |
| Target Sequences: | NM_002190 NP_002181.1 Q16552 |
Publications (3)
1
Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M. PloS one. 2016 11:e0154817. (IHC; Human)
[Full Text Article]
[PubMed:27152519]
[PMC:PMC4859486]
Related Antibodies: LS-B8323.
2
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. Sherrie J Divito, Anders T Aasebø, Tiago R Matos, Pei-Chen Hsieh, Matthew Collin, Christopher P Elco, John T O'Malley, Espen S Bækkevold, Henrik Reims, Tobias Gedde-Dahl, Michael Hagerstrom, Jude Hilaire, John W Lian, Edgar L Milford, Geraldine S Pinkus, Vincent T Ho, Robert J Soiffer, Haesook T Kim, Martin C Mihm, Jerome Ritz, Indira Guleria, Corey S Cutler, Rachael A Clark, Frode L Jahnsen, Thomas S Kupper. The Journal of clinical investigation. 2020 September;130:4624-4636. [Full Text Article]
[PubMed:32516138]
[PMC:PMC7456221]
Related Antibodies: LS-C104427.
3
Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions. E Hagforsen, M Lampinen, A Paivandy, S Weström, H Velin, S Öberg, G Pejler, O Rollman. The British journal of dermatology. 2017 July;177:179-187. [Full Text Article]
[PubMed:28117878]
Related Antibodies: LS-B7397.
☰ Filters
Products
Proteins
(41)
Type
Over-Expression Lysate
(2)
Recombinant
(39)
Target
IL17A
(41)
Application
SDS-PAGE
(1)
Product Group
Coronavirus Antibodies Proteins cDNAs
(40)
Cytokine Release Syndrome
(40)
Cytokine Release Syndrome Proteins
(40)
Format
Animal-free
(1)
Publications
No
(41)
Tag
6His, C-terminus
(8)
6His, N-terminus
(1)
GST
(2)
GST, N-terminus
(1)
His
(2)
His, C-Terminal
(1)
His, N-Terminal
(1)
His,N-terminus
(2)
Human IgG1 Fc, C-terminus
(1)
Human Mutant IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Cynomolgus
(1)
Dog
(1)
Human
(24)
Monkey
(1)
Mouse
(7)
Pig
(1)
Rabbit
(3)
Rat
(1)
Source
293T Cells
(1)
Baculovirus
(1)
CHO Cells
(2)
E. coli
(16)
HEK 293 Cells
(4)
Human
(2)
Human Cells
(3)
Insect Cells
(1)
Mammalian Cells
(4)
Wheat Germ Extract
(1)
Yeast
(6)
Purification
Purified
(10)
Low Endotoxin Level
Low endotoxin level
(25)
Biologically Active
Biologically active
(16)
Animal-free
Animal-free
(1)
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
20.5 kDa
50 µg/$453; 10 µg/$303; 1 mg/$2,837; 500 µg/$1,987
HEK 293 Cells
Human Mutant IgG1 Fc, N-terminus
Biologically active
Less than 5.0 EU/mg protein (determined by LAL method).
~42 kDa (SDS-PAGE)
50 µg/$442
HEK 293 Cells
Human IgG1 Fc, C-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
~42 kDa (SDS-PAGE)
50 µg/$505
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
31.3 kDa
5 µg/$268; 25 µg/$349
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.2kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
15.1 kDa
20 µg/$1,107
Human
None
17.1kDa
50 µg/$662; 10 µg/$316; 200 µg/$1,242; 100 µg/$1,045; 1 mg/$2,488; 500 µg/$1,989; 5 mg/$4,621; 2 mg/$2,680
293T Cells
Myc-DDK (Flag)
17.5 kDa
20 µg/$150
Yeast
His
17.3 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
E. coli
GST
42.5 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
E. coli
GST
42.7 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
CHO Cells
His, C-Terminal
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
14-22 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$278; 1 mg/$1,612
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15-22 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$278; 1 mg/$1,612
E. coli
6His, N-terminus
17.6 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
15.26kD
10 µg/$248; 50 µg/$321; 500 µg/$1,353; 1 mg/$1,725
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.5kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
HEK 293 Cells
Myc-DDK (Flag)
17.5 kDa
100 µg/$494
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 137 amino acid N-terminal methionylated recombinant protein has a predicted molecular mass of 15,666 Da. This protein exists as a disulfide-linked homodimer. The DTT-reduced protein migrates at approximately 16kDa by SDS-PAGE. The non-reduced protein
10 µg/$306; 25 µg/$359; 100 µg/$689
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 133 amino acid recombinant protein has a predicted molecular mass of 14,978 Da. This protein exists as a disulfide-linked homodimer. The DTT-reduced protein migrates at approximately 15kDa by SDS-PAGE. The non-reduced protein migrates as a homodimer,
10 µg/$306; 25 µg/$383; 100 µg/$625; 500 µg/$1,595
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
15.26 kDa
50 µg/$356; 10 µg/$259; 1 mg/$2,269; 500 µg/$1,639
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.5 kDa
10 µg/$281; 50 µg/$389
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.2 kDa
10 µg/$288; 50 µg/$436
E. coli
His, N-Terminal
20kDa
10 µg/$277; 50 µg/$420; 200 µg/$837; 100 µg/$670; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113
Viewing 1-25
of 41
product results
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