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IL17A

interleukin 17A

IL17A is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Gene Name: interleukin 17A
Family/Subfamily: Interleukin
Synonyms: IL17A, CTLA-8, CTLA8, Interleukin-17A, Interleukin 17A, IL-17, IL-17A, IL17
Target Sequences: NM_002190 NP_002181.1 Q16552

Publications (3)

1
Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. Roth S, Spalinger MR, Gottier C, Biedermann L, Zeitz J, Lang S, Weber A, Rogler G, Scharl M. PloS one. 2016 11:e0154817. (IHC; Human) [Full Text Article] [PubMed:27152519] [PMC:PMC4859486] Related Antibodies: LS-B8323.
2
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. Sherrie J Divito, Anders T Aasebø, Tiago R Matos, Pei-Chen Hsieh, Matthew Collin, Christopher P Elco, John T O'Malley, Espen S Bækkevold, Henrik Reims, Tobias Gedde-Dahl, Michael Hagerstrom, Jude Hilaire, John W Lian, Edgar L Milford, Geraldine S Pinkus, Vincent T Ho, Robert J Soiffer, Haesook T Kim, Martin C Mihm, Jerome Ritz, Indira Guleria, Corey S Cutler, Rachael A Clark, Frode L Jahnsen, Thomas S Kupper. The Journal of clinical investigation. 2020 September;130:4624-4636. [Full Text Article] [PubMed:32516138] [PMC:PMC7456221] Related Antibodies: LS-C104427.
3
Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions. E Hagforsen, M Lampinen, A Paivandy, S Weström, H Velin, S Öberg, G Pejler, O Rollman. The British journal of dermatology. 2017 July;177:179-187. [Full Text Article] [PubMed:28117878] Related Antibodies: LS-B7397.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).