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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
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IL12RB2
interleukin 12 receptor, beta 2
IL12RB2 is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene.
| Gene Name: | interleukin 12 receptor, beta 2 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL12RB2, Il-12R beta2, IL-12R-beta-2, IL-12 receptor beta 2, Il-12 receptor beta2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, RP11-102M16.1, IL-12RB2 |
| Target Sequences: | NM_001559 NP_001550.1 Q99665 |
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