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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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IL12RB1 / CD212
interleukin 12 receptor, beta 1
IL12RB1 / CD212 is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
| Gene Name: | interleukin 12 receptor, beta 1 |
| Family/Subfamily: | Interleukin |
| Synonyms: | IL12RB1, CD212, IL-12R subunit beta-1, IL-12R-beta-1, IL12R, Interleukin-12 receptor, IL-12 receptor subunit beta-1, IL-12R-BETA1, IL-12RB1, CD212 antigen, IL-12 receptor beta component, IL12RB |
| Target Sequences: | NM_005535 NP_005526.1 P42701 |
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