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IL10RB

interleukin 10 receptor, beta

Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene Name: interleukin 10 receptor, beta
Family/Subfamily: Interleukin
Synonyms: IL10RB, CDW210B, CDw210b antigen, D21S66, IL-10R subunit 2, IBD25, IL-10R2, Interleukin 10 receptor, beta, IL-10 receptor subunit beta, IL-10R subunit beta, IL-10RB, CRF2-4, CRFB4, D21S58
Target Sequences: NM_000628 NP_000619.3 Q08334

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).