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IL-33

interleukin 33

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).

Gene Name: interleukin 33
Family/Subfamily: Interleukin
Synonyms: IL33, C9orf26, DVS27, DVS27-related protein, IL-1F11, IL-33, Interleukin-33, NFEHEV, NF-HEV, Interleukin-1 family member 11, NFHEV, IL1F11, Interleukin 33, RP11-575C20.2
Target Sequences: NM_033439 NP_254274.1 O95760

Publications (5)

1
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article] [PubMed:30185520] Related Antibodies: LS-C104697.
2
Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway. George S Hussey, Jenna L Dziki, Yoojin C Lee, Joseph G Bartolacci, Marissa Behun, Heth R Turnquist, Stephen F Badylak. Journal of immunology and regenerative medicine. 2019 March;3:26-35. [Full Text Article] [PubMed:31656879] [PMC:PMC6814021]
3
A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes. Eva Haas , Rana D Incebacak , Thomas Hentrich , Chrisovalantou Huridou , Thorsten Schmidt , Nicolas Casadei , Yacine Maringer , Carola Bahl , Frank Zimmermann, James D Mills, Eleonora Aronica, Olaf Riess , Julia M Schulze-Hentrich , Jeannette Hübener-Schmid. Molecular neurobiology. 2022 Jan;;59:495-522. [Full Text Article] [PubMed:34716557] [PMC:PMC8786755] Related Antibodies: LS-C294906.
4
Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model. Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang, Jui-Hung Yen. Stem cell research & therapy. 2022 July;13:357. [Full Text Article] [PubMed:35883204] [PMC:PMC9327360]
5
Elevations in Th2-initiating cytokines (IL-33, IL-25, TSLP) in lesional skin from Chronic Spontaneous ("Idiopathic") Urticaria. Clark P, Maurer M, Ying S. The British journal of dermatology. Dec; [Full Text Article] [PubMed:25523947] Related Antibodies: LS-C104697.
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☰ Filters
Products
Proteins (38)
Over-Expression Lysate (2)
Recombinant (36)
IL-33 (38)
Animal-free (1)
No (38)
6His, N-terminus (2)
GST (3)
GST, N-terminus (1)
His (7)
His, N-Terminal (2)
His,N-terminus (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (21)
Monkey-Rhesus (1)
Mouse (12)
Pig (1)
Rat (2)
293T Cells (1)
E. coli (34)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (12)
Low endotoxin level (25)
Biologically active (11)
Animal-free (1)
IL-33 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
30.6 kDa
20 µg/$150
IL-33 Protein - Recombinant Interleukin 33 By SDS-PAGE
Select
E. coli
His, N-Terminal
34.6 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
Select
E. coli
GST
45 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
IL-33 Protein - Mouse IL-33 induces the proliferation of D10.G4.1 mouse T lymphocytes in a dose dependent manner.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (Less than 0.1 EU/µg) (determined by LAL method).
The 158 amino acid recombinant protein has a predicted molecular mass of approximately 17,554 Da. The DTT-reduced and non-reduced protein migrate at approximately 20 kDa by SDS-PAGE. The N-terminal amino acid is Serine.
10 µg/$344; 25 µg/$459; 100 µg/$1,000; 500 µg/$2,235
IL-33 Protein
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18 kDa
10 µg/$291; 100 µg/$731; 1 mg/$2,851
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.9 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.3kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
IL-33 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.6kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
IL-33 Protein - Recombinant Interleukin 33 By SDS-PAGE
Select
E. coli
GST
43.3 kDa
10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278
IL-33 Protein - Recombinant Interleukin 33 By SDS-PAGE
Select
E. coli
His-T7
21.5 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
IL-33 Protein - Recombinant Interleukin 33 By SDS-PAGE
Select
E. coli
His
13.1 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Select
E. coli
His
18.5 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
18.0 kDa (SDS-PAGE)
50 µg/$478; 10 µg/$296; 1 mg/$2,653
IL-33 Protein - 12.5% SDS-PAGE of human IL33 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
57.2 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
20.29kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
IL-33 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
30.6 kDa
100 µg/$494
IL-33 Protein
Select
E. coli
His, N-Terminal
30.6 kDa
50 µg/$419
IL-33 Protein - D10.G4.1 cell proliferation induced by human IL-33
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 159 amino acid recombinant protein has a predicted molecular mass of approximately 18 kD. The DTT-reduced protein migrates at approximately 19 kD and non-reduced protein migrates at approximately 20 kD by SDS-PAGE. The N-terminal amino acid is Serine.
10 µg/$359; 25 µg/$474; 100 µg/$1,097; 500 µg/$2,336
IL-33 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.6 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.3 kDa
20 µg/$360; 100 µg/$728
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
18.1 kDa
10 µg/$317; 50 µg/$524
Select
E. coli
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
20.3 kDa
10 µg/$317; 50 µg/$524
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
17.6 kDa
20 µg/$360; 100 µg/$728
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
17.5 kDa
10 µg/$364; 1 mg/$4,545
Viewing 1-25 of 38 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).