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IL-10
interleukin 10
IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
| Gene Name: | interleukin 10 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IL10, CSIF, GVHDS, IL-10, IL10A, Interleukin-10, Interleukin 10, TGIF |
| Target Sequences: | NM_000572 NP_000563.1 P22301 |
Publications (6)
1
Antibodies to human IL-10 neutralize ebvIL-10-mediated cytokine suppression but have no effect on cmvIL-10 activity. Brodeur ND, Spencer JV. Virus research. 2010 153:265-8. (WB; Human)
[Full Text Article]
[PubMed:20728483]
[PMC:PMC3769974]
Related Antibodies: LS-C47137.
2
Skin-Derived Mesenchymal Stem Cells Alleviate Atherosclerosis via Modulating Macrophage Function. Li Q, Sun W, Wang X, Zhang K, Xi W, Gao P. Stem cells translational medicine. 2015 November;4:1294-301. (Mouse)
[Full Text Article]
[PubMed:26400926]
[PMC:PMC4622403]
Related Antibodies: LS-B4913.
3
PPAR? agonist rosiglitazone alters the temporal and spatial distribution of inflammation during abdominal aortic aneurysm formation. Wen-Da Wang, Rui Sun, Yue-Xin Chen. Molecular medicine reports. 2018 September;18:3421-3428. [Full Text Article]
[PubMed:30066924]
Related Antibodies: LS-C331959.
☰ Filters
Products
Proteins
(70)
Type
Over-Expression Lysate
(2)
Recombinant
(68)
Target
IL-10
(70)
Product Group
Coronavirus Antibodies Proteins cDNAs
(70)
Cytokine Release Syndrome
(70)
Cytokine Release Syndrome Proteins
(70)
Format
Animal-free
(1)
Publications
No
(70)
Tag
10His, C-terminus
(2)
10His, N-terminus + Myc, C-terminus
(1)
6His, N-terminus
(1)
6His-B2M, N-terminus
(1)
6His-SUMO, N-terminus
(1)
GST
(2)
GST, N-terminus
(1)
His
(9)
His, N-Terminal
(5)
His,C-terminus
(1)
His-GST
(2)
His-GST, N-terminus
(1)
His-S
(1)
His-T7
(4)
Human IgG1 Fc
(1)
Human Mutant IgG1 Fc
(1)
Mouse Mutant IgG2a Fc
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(3)
Dog
(2)
Horse
(1)
Human
(31)
Marmoset
(1)
Mouse
(14)
Pig
(1)
Rabbit
(2)
Rat
(7)
Rhesus monkey
(6)
Sheep
(1)
Source
293F Cells
(4)
293T Cells
(1)
Baculovirus
(2)
CHO Cells
(6)
E. coli
(35)
HEK 293 Cells
(6)
Human
(1)
Human Cells
(1)
Mammalian Cells
(2)
NS1 Cells
(1)
Wheat Germ Extract
(2)
Yeast
(6)
Purification
Purified
(28)
Low Endotoxin Level
Low endotoxin level
(27)
Biologically Active
Biologically active
(24)
Animal-free
Animal-free
(1)
Mammalian Cells
10His, C-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
E. coli
None
Biologically active
18.6 kDa
10 µg/$388; 100 µg/$1,466; 500 µg/$3,025
E. coli
His, N-Terminal
22.1kDa
10 µg/$297; 50 µg/$542; 200 µg/$1,065; 100 µg/$865; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
Rhesus monkey IL-10 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa19-178) - LS-G55959
Baculovirus
10His, N-terminus + Myc, C-terminus
100 µg/$920; 20 µg/$411; 1 mg/$1,808
E. coli
GST
46 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HEK 293 Cells
His,C-terminus
Biologically active
Less than 0.01 EU/µg protein (determined by LAL method).
~18 kDa (SDS-PAGE)
10 µg/$358
293F Cells
His, N-Terminal
22kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.7 kDa
2 µg/$268; 10 µg/$349
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
19.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
E. coli
None
1 mg/$1,756; 100 µg/$611; 20 µg/$447
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Human
None
50 µg/$837; 10 µg/$345; 200 µg/$1,476; 100 µg/$1,255; 1 mg/$2,783; 500 µg/$2,279; 5 mg/$5,860; 2 mg/$3,125
Baculovirus
10His, C-terminus
100 µg/$810; 20 µg/$387; 1 mg/$1,678
E. coli
6His-B2M, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
293T Cells
Myc-DDK (Flag)
20.52 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
18.6 kDa
20 µg/$1,107
E. coli
His-T7
22.2 kDa
10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298
E. coli
His-GST
51.0 kDa
50 µg/$497; 10 µg/$290; 200 µg/$992; 100 µg/$795; 1 mg/$2,134; 500 µg/$1,658; 5 mg/$3,473; 2 mg/$2,324
E. coli
His-T7
22.5 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-T7
24.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-T7
22.5 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
Yeast
His
20.6 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
Yeast
His
20.7 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
Yeast
His
20.57 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
Viewing 26-50
of 70
product results
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