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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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IL-10

interleukin 10

IL-10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

Gene Name: interleukin 10
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IL10, CSIF, GVHDS, IL-10, IL10A, Interleukin-10, Interleukin 10, TGIF
Target Sequences: NM_000572 NP_000563.1 P22301

Publications (2)

1
Antibodies to human IL-10 neutralize ebvIL-10-mediated cytokine suppression but have no effect on cmvIL-10 activity. Brodeur ND, Spencer JV. Virus research. 2010 153:265-8. (WB; Human) [Full Text Article] [PubMed:20728483] [PMC:PMC3769974] Related Antibodies: LS-C47137.
2
Skin-Derived Mesenchymal Stem Cells Alleviate Atherosclerosis via Modulating Macrophage Function. Li Q, Sun W, Wang X, Zhang K, Xi W, Gao P. Stem cells translational medicine. 2015 November;4:1294-301. (Mouse) [Full Text Article] [PubMed:26400926] [PMC:PMC4622403] Related Antibodies: LS-B4913.

Viewing 1-25 of 94 items
IL-10 Protein - Eukaryotic Interleukin 10 (IL10) by SDS-PAGE
Select
293F Cells
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
20kDa
10µg   $325.00; 50µg   $620.00; 200µg   $1,230.00; 100µg   $995.00; 1mg   $3,720.00; 500µg   $1,650.00
Select
HEK 293 Cells
None
Biologically active
2µg   $195.00; 10µg   $255.00; 100µg   $1,155.00
IL-10 Protein
Select
E. coli
None
Biologically active
18.6 kDa
2µg   $225.00; 10µg   $315.00; 100µg   $1,320.00; 250µg   $2,385.00; 1mg   $4,245.00; 500µg   $3,105.00
IL-10 Protein - Eukaryotic Interleukin 10 (IL10) by SDS-PAGE
Select
293F Cells
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
22kDa
10µg   $265.00; 50µg   $435.00; 200µg   $815.00; 100µg   $650.00; 1mg   $2,430.00; 500µg   $1,080.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.7 kDa
2µg   $215.00; 10µg   $285.00
IL-10 Protein
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100µg   0.25mg/ml   $275.00; 0.5mg   0.25mg/ml   $485.00
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2µg   $225.00; 10µg   $295.00
Select
E. coli
His
2µg   $195.00; 10µg   $255.00; 1mg   $4,650.00
Select
E. coli
None
Biologically active
2µg   $195.00; 10µg   $255.00; 1mg   $4,950.00
Select
E. coli
None
Biologically active
2µg   $195.00; 10µg   $255.00; 1mg   $4,950.00
Select
E. coli
None
Biologically active
2µg   $195.00; 10µg   $255.00; 1mg   $4,950.00
Select
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50µg   $395.00; 10µg   $295.00
Select
E. coli
His
Less than 0.1 EU/µg protein (determined by LAL method).
50µg   $665.00; 10µg   $285.00
Select
NS1 Cells
Human mutant IgG1 Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
50µg   $395.00; 10µg   $295.00
Select
CHO Cells
Mouse mutant IgG2a Fc
Biologically active
Less than 0.06 EU/µg protein (determined by LAL method).
50µg   $425.00; 10µg   $315.00
IL-10 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
20.52 kDa
20µg   $195.00
IL-10 Protein
Select
E. coli
None
Biologically active
18.7 kDa
2µg   $225.00; 10µg   $315.00; 100µg   $1,320.00; 250µg   $2,385.00; 1mg   $4,245.00; 500µg   $3,105.00
IL-10 Protein
Select
HEK 293 Cells
None
Biologically active
Less than 1.0 EU/µg protein.
17 kDa
50µg   $1,590.00; 10µg   $405.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
18.7 kDa
1mg   $8,010.00; 10µg   $365.00
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein.
19.6 kDa
50µg   $800.00; 1mg   $6,480.00; 10µg   $325.00
IL-10 Protein - Recombinant Interleukin 10 By SDS-PAGE
Select
E. coli
His + T7
22.5 kDa
10µg   $295.00; 50µg   $495.00; 100µg   $695.00; 200µg   $1,005.00; 1mg   $2,580.00; 500µg   $1,140.00
IL-10 Protein - Recombinant Interleukin 10 By SDS-PAGE
Select
E. coli
His + T7
22.2 kDa
10µg   $295.00; 50µg   $515.00; 100µg   $695.00; 200µg   $1,020.00; 1mg   $2,610.00; 500µg   $1,155.00
IL-10 Protein - Recombinant Interleukin 10 By SDS-PAGE
Select
E. coli
His + GST
51.0 kDa
50µg   $515.00; 10µg   $295.00; 200µg   $1,035.00; 100µg   $710.00; 1mg   $2,670.00; 500µg   $1,185.00
IL-10 Protein - Recombinant Interleukin 10 By SDS-PAGE
Select
E. coli
His + T7
24.3 kDa
10µg   $265.00; 50µg   $425.00; 100µg   $545.00; 200µg   $800.00; 1mg   $2,040.00; 500µg   $905.00
IL-10 Protein - Recombinant Interleukin 10 By SDS-PAGE
Select
E. coli
His + T7
22.5 kDa
10µg   $265.00; 50µg   $425.00; 100µg   $545.00; 200µg   $800.00; 1mg   $2,040.00; 500µg   $905.00

Viewing 1-25 of 94 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).