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IKZF3 / AIOLOS
IKAROS family zinc finger 3 (Aiolos)
IKZF3 / AIOLOS is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
| Gene Name: | IKAROS family zinc finger 3 (Aiolos) |
| Synonyms: | IKZF3, AIO, AIOLOS, Zinc finger protein Aiolos, ZNFN1A3 |
| Target Sequences: | NM_012481 NP_036613.2 Q9UKT9 |
Publications (1)
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