IKBKB / IKK2 / IKK Beta

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

IKBKB / IKK2 / IKK Beta (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His-GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human IKBKB / IKK2 / IKK Beta Protein (Recombinant His-GST, N-terminus) (Asp246-Val528) - LS-G133237

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

62.3kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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IKBKB / IKK2 / IKK Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118518

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.4 kDa

Price:

100 µg/$710

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Human IKBKB / IKK2 / IKK Beta Protein (Recombinant GST) (Full Length) - LS-G29022

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53.79 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse IKBKB / IKK2 / IKK Beta Protein (Recombinant His-T7) (aa1-231) - LS-G26034

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.2 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human IKBKB / IKK2 / IKK Beta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67660

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.4 kDa

Price:

20 µg/$1,107

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Human IKBKB / IKK2 / IKK Beta Protein (Recombinant GST, N-terminus) (aa3-120) - LS-G58966

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IKBKB / IKK2 / IKK Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80405

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.4 kDa

Price:

20 µg/$215

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