IgG2 Fab'2

The fragment antigen-binding (Fab fragment) is a region on an antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. These domains shape the paratope — the antigen-binding site — at the amino terminal end of the monomer. The two variable domains bind the epitope on their specific antigens. In an experimental setting, Fc and Fab fragments can be generated in the laboratory. The enzyme papain can be used to cleave an immunoglobulin monomer into two Fab fragments and an Fc fragment. The enzyme pepsin cleaves below hinge region, so a F(ab')2 fragment and a pFc' fragment is formed. Recently another enzyme for generation of F(ab')2 has been commercially available. The enzyme IdeS (Immunoglobulin degrading enzyme from Streptococcus pyogenes, trade name FabRICATOR) cleaves IgG in a sequence specific manner at neutral pH. The F(ab')2 fragment can be split into two Fab' fragments by mild reduction.

IgG2 Fab'2 Target Details

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Products

Antibodies (2)

Type

Primary (2)

Target

IgG2 Fab'2 (2)

Reactivity

Human (2)

Application

WB (2)

ELISA (2)

Host

goat (2)

Isotype

IgG (2)

Clonality

polyclonal pc (2)

Format

AP Conjugated (1)

HRP Conjugated (1)

Publications

No (2)

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IgG2 Fab'2 Antibody (HRP) LS-C745895

Antibody:

IgG2 Fab'2 Goat anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

0.5 ml/$356

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IgG2 Fab'2 Antibody (AP) LS-C745872

Antibody:

IgG2 Fab'2 Goat anti-Human Polyclonal (AP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

AP Conjugated

Price:

0.5 ml/$464

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