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IGF2R / CD222

insulin-like growth factor 2 receptor

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Gene Name: insulin-like growth factor 2 receptor
Synonyms: IGF2R, CD222 antigen, CIMPR, CI Man-6-P receptor, CI-MPR, IGF-II receptor, MPR 300, MPR1, MPRI, M6P-R, M6P/IGF2R, CD222, M6P/IGF2 receptor
Target Sequences: NM_000876 NP_000867.2 P11717

Publications (1)

1
Secretion of parathyroid hormone may be coupled to insulin secretion in humans. Marie Reeberg Sass, Nicolai Jacob Wewer Albrechtsen, Jens Pedersen, Kristine Juul Hare, Nis Borbye-Lorenzen, Katalin Kiss, Tina Vilsbøll, Filip Krag Knop, Steen Seier Poulsen, Niklas Rye Jørgensen, Jens Juul Holst, Cathrine Ørskov, Bolette Hartmann. Endocrine connections. 2020 July;9:747-754. [Full Text Article] [PubMed:32698134] [PMC:PMC7424341]

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Proteins (5)
Recombinant (5)
IGF2R / CD222 (5)
No (5)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
His-S (1)
Human (3)
Mouse (1)
Rat (1)
E. coli (4)
Wheat Germ Extract (1)
IGF2R / CD222 Protein - Recombinant Insulin Like Growth Factor 2 Receptor By SDS-PAGE
Select
E. coli
His, N-Terminal
28.3 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
IGF2R / CD222 Protein - Recombinant Insulin Like Growth Factor 2 Receptor By SDS-PAGE
Select
E. coli
His, N-Terminal
28.4 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
IGF2R / CD222 Protein - Recombinant Mannose-6-Phosphate Receptor By SDS-PAGE
Select
E. coli
His-S
21.6 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
IGF2R / CD222 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
IGF2R / CD222 Protein - Recombinant Insulin Like Growth Factor 2 Receptor By SDS-PAGE
Select
E. coli
His
31.9 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).