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IGF2

insulin-like growth factor 2 (somatomedin A)

The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Gene Name: insulin-like growth factor 2 (somatomedin A)
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: IGF2, C11orf43, IGF-II, PP9974, Somatomedin-A
Target Sequences: NM_000612 NP_000603.1 P01344

Publications (4)

1
Maternal supplementation of energy and protein, but not methionine hydroxy analog, enhanced postnatal growth and response to vaccination in Bos indicus-influenced beef offspring. Philipe Moriel, Marcelo Vedovatto, Elizabeth A Palmer, Rhaiza A Oliveira, Hiran Marcelo Silva, Juliana Ranches, Joao M B Vendramini. Journal of animal science. 2020 May;98: [Full Text Article] [PubMed:32309862] [PMC:PMC7228674]
2
Monensin supplementation during late gestation of beef cows alters maternal plasma concentrations of insulin-like growth factors 1 and 2 and enhances offspring preweaning growth. Marcelo Vedovatto, Vinicius Izquierdo, Elizabeth Palmer, Rhaiza A Oliveira, Hiran M Silva, João M B Vendramini, Philipe Moriel. Translational animal science. 2022 July;6:txac105. [Full Text Article] [PubMed:36046092] [PMC:PMC9423031]
3
Frequency of maternal supplementation of energy and protein during late gestation modulates preweaning growth of their beef offspring. Vinicius Izquierdo, Marcelo Vedovatto, Elizabeth A Palmer, Rhaiza A Oliveira, Hiran M Silva, João M B Vendramini, Philipe Moriel. Translational animal science. 2022 July;6:txac110. [Full Text Article] [PubMed:36090697] [PMC:PMC9449678]
4
The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells. Tada Y, Yamaguchi Y, Kinjo T, Song X, Akagi T, Takamura H, Ohta T, Yokota T, Koide H. Oncogene. 2014 Feb;34:752-60. [Full Text Article] [PubMed:24469060] Related Antibodies: LS-B7415.
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☰ Filters
Products
Proteins (27)
Over-Expression Lysate (6)
Recombinant (20)
IGF2 (27)
Animal-free (1)
No (27)
6His, N-terminus (1)
GST (3)
GST, N-terminus (1)
His (4)
Myc-DDK (Flag) (6)
Human (20)
Mouse (2)
Rat (2)
293T Cells (3)
E. coli (18)
HEK 293 Cells (3)
Wheat Germ Extract (3)
Purified (10)
Low endotoxin level (10)
Biologically active (8)
Animal-free (1)
IGF2 Protein - Recombinant Insulin Like Growth Factor 2 By SDS-PAGE
Select
E. coli
His
9.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
10 µg/$258; 100 µg/$372; 1 mg/$1,530
IGF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.14 kDa
100 µg/$494
IGF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
26.2 kDa
100 µg/$494
Select
E. coli
None
Less than 0.1 ng/µg protein.
7.5 kDa
10 µg/$329; 50 µg/$412; 1000 µg/$1,795
IGF2 Protein - MCF-7 cell proliferation induced by mouse IGF-II.
Select
E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
The 67 amino acid recombinant protein has a predicted molecular mass of approximately 7.4 kD. The DTT-reduced and non-reduced protein migrate at approximately 9 kD by SDS-PAGE. The N-terminal amino acid is Ala.
25 µg/$306
Select
Wheat Germ Extract
GST
38.5 kDa
10 µg/$479; 25 µg/$670
IGF2 Protein - 12.5% SDS-PAGE of human IGF2 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
45.43 kDa
2 µg/$439
IGF2 Protein - Recombinant Insulin Like Growth Factor 2 By SDS-PAGE
Select
E. coli
His
21.0 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Select
E. coli
GST
44.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
7.6 kDa (SDS-PAGE)
50 µg/$296; 10 µg/$253; 1 mg/$907
IGF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.14 kDa
20 µg/$150
IGF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
20.14 kDa
20 µg/$150
IGF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
26.2 kDa
20 µg/$150
IGF2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
IGF2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
20.14 kDa
100 µg/$494
IGF2 Protein
Select
E. coli
None
Biologically active
7.5 kDa
10 µg/$282; 100 µg/$483; 500 µg/$1,003
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
10 µg/$268; 50 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$282; 50 µg/$370
IGF2 Protein
Select
E. coli
None
50 µg/$411; 250 µg/$985; 10 µg/$276
Select
E. coli
His
11.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
IGF2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
8.91 kDa
50 µg/$453; 10 µg/$298; 1 mg/$2,064; 500 µg/$1,470
IGF2 Protein - MCF-7 cell proliferation induced by human IGF-II.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 67 amino acid recombinant protein has a predicted molecular mass of approximately 7.47 kD. The DTT-reduced and non-reduced protein migrate at approximately 10 kD by SDS-PAGE. The N-terminal amino acid is Ala.
25 µg/$314; 100 µg/$420; 500 µg/$944
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
8.9 kDa
20 µg/$360; 100 µg/$728
IGF2 Protein
Select
E. coli
6His, N-terminus
7.5 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Viewing 1-25 of 27 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).