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IGF1

insulin-like growth factor 1 (somatomedin C)

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.

Gene Name:	insulin-like growth factor 1 (somatomedin C)
Family/Subfamily:	Hormone , not assigned-Hormone
Synonyms:	IGF1, IGF-IA, IGF-IB, IGFI, IBP1, IGF-I, Insulin-like growth factor 1, Insulin-like growth factor I, Insulin-like growth factor IA, Insulin-like growth factor IB, Mechano growth factor, Somatomedin-C, IGF1A, MGF
Target Sequences:	NM_000618 NP_000609.1 P05019

Publications (5)

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, et al. Nature communications. 2017 8:607. (WB; Human) [Full Text Article] [PubMed:28928360] Related Antibodies: LS-C7504.

Cytokine Mixtures Mimicking Secretomes From Mesenchymal Stem Cells Improve Medication-Related Osteonecrosis of the Jaw in a Rat Model. Ogata K, Matsumura M, Moriyama M, Katagiri W, Hibi H, Nakamura S. JBMR plus. 2017 September;2:69-80. [Full Text Article] [PubMed:30283893] [PMC:PMC6124208] Related Antibodies: LS-C36891.

A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. Cell proliferation. 2017 June;50: [Full Text Article] [PubMed:28133828] Related Antibodies: LS-C36891.

Biomaterial and implant induced ossification: in vitro and in vivo findings. Pekka K Vallittu, Jussi P Posti, Jaakko M Piitulainen, Willy Serlo, Jorma A Määttä, Terhi J Heino, Stefania Pagliari, Stina M Syrjänen, Giancarlo Forte. Journal of tissue engineering and regenerative medicine. 2020 August;14:1157-1168. [Full Text Article] [PubMed:32415757] [PMC:PMC7496445] Related Antibodies: LS-C388624.

Multiple protein biomarker assessment for recombinant bovine somatotropin (rbST) abuse in cattle. Ludwig SK, Smits NG, van der Veer G, Bremer MG, Nielen MW. PloS one. 2013 7:e52917. (Flo; Human) [Full Text Article] [PubMed:23300820] [PMC:PMC3531382] Related Antibodies: LS-C392250.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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