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IGF1
insulin-like growth factor 1 (somatomedin C)
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.
| Gene Name: | insulin-like growth factor 1 (somatomedin C) |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IGF1, IGF-IA, IGF-IB, IGFI, IBP1, IGF-I, Insulin-like growth factor 1, Insulin-like growth factor I, Insulin-like growth factor IA, Insulin-like growth factor IB, Mechano growth factor, Somatomedin-C, IGF1A, MGF |
| Target Sequences: | NM_000618 NP_000609.1 P05019 |
Publications (5)
1
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Somasundaram R, Zhang G, Fukunaga-Kalabis M, Perego M, Krepler C, Xu X, Wagner C, Hristova D, Zhang J, Tian T, Wei Z, Liu Q, Garg K, Griss J, Hards R, Maurer M, Hafner C, Mayerhöfer M, Karanikas G, Jalili A, Bauer-Pohl V, Weihsengruber F, Rappersberger K, Koller J, Lang R, Hudgens C, Chen G, Tetzlaff M, Wu L, Frederick DT, Scolyer RA, Long GV, Damle M, Ellingsworth C, Grinman L, Choi H, Gavin BJ, Dunagin M, Raj A, Scholler N, Gross L, Beqiri M, Bennett K, Watson I, Schaider H, et al. Nature communications. 2017 8:607. (WB; Human)
[Full Text Article]
[PubMed:28928360]
Related Antibodies: LS-C7504.
2
Cytokine Mixtures Mimicking Secretomes From Mesenchymal Stem Cells Improve Medication-Related Osteonecrosis of the Jaw in a Rat Model. Ogata K, Matsumura M, Moriyama M, Katagiri W, Hibi H, Nakamura S. JBMR plus. 2017 September;2:69-80. [Full Text Article]
[PubMed:30283893]
[PMC:PMC6124208]
Related Antibodies: LS-C36891.
3
A defined mix of cytokines mimics conditioned medium from cultures of bone marrow-derived mesenchymal stem cells and elicits bone regeneration. Katagiri W, Sakaguchi K, Kawai T, Wakayama Y, Osugi M, Hibi H. Cell proliferation. 2017 June;50: [Full Text Article]
[PubMed:28133828]
Related Antibodies: LS-C36891.
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Cancer
IGF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$485
IGF1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IGF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, RIA
Unconjugated
50 µl/$717
IGF1 Rabbit anti-Human Polyclonal (aa80-96) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
IGF1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$567
IGF1 Rabbit anti-Human Polyclonal (aa115-144) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
IGF1 Goat anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
IGF1 Goat anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
IGF1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$860
IGF1 Goat anti-Human Polyclonal (aa100-109) Antibody
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
IGF1 Mouse anti-Human Monoclonal (SPM406) Antibody
Rabbit, Mouse, Rat, Human
Flo, IF
Unconjugated
20 µg/$371; 100 µg/$574
IGF1 Mouse anti-Human Monoclonal Antibody
ELISA, RIA
Unconjugated
200 µg/$1,355
IGF1 Mouse anti-Human Monoclonal (M23) Antibody
Mouse, Rat, Human
Flo, Func, IF, WB
Unconjugated
20 µg/$371; 100 µg/$574
IGF1 Mouse anti-Human Monoclonal (AT6F8) Antibody
Human
ELISA, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
IGF1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$842
IGF1 Mouse anti-Human Monoclonal (Preservative Free) (3H12-F10-G8) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
IGF1 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$518
IGF1 Mouse anti-Human Monoclonal (aa1-151) (OTI4B12) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
IGF1 Mouse anti-Human Monoclonal (aa1-151) (OTI3A6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
IGF1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
1 ml/$550
IGF1 Mouse anti-Human Monoclonal (M23/ILG1-001) Antibody
Human
ELISA, RIA
Unconjugated
0.2 mg/$486
IGF1 Mouse anti-Human Monoclonal (M23) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 mg/$618
IGF1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, RIA
HRP Conjugated
100 µl/$951
IGF1 Rabbit anti-Human Polyclonal (aa115-144) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
IGF1 Rabbit anti-Human Polyclonal (aa115-144) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
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