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IFT74 / CCDC2

intraflagellar transport 74 homolog (Chlamydomonas)

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.

Gene Name: intraflagellar transport 74 homolog (Chlamydomonas)
Synonyms: IFT74, CCDC2, CMG-1, CMG1
Target Sequences: NM_025103 NP_079379.2 Q96LB3

Publications (2)

1
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chi A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Single. BMC neurology. 2006 6:44. [PubMed:17166276] [PMC:PMC1764752] Related Antibodies: LS-B2293.
2
Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. Boldt K, Mans DA, Won J, van Reeuwijk J, Vogt A, Kinkl N, Letteboer SJ, Hicks WL, Hurd RE, Naggert JK, Texier Y, den Hollander AI, Koenekoop RK, Bennett J, Cremers FP, Gloeckner CJ, Nishina PM, Roepman R, Ueffing M. The Journal of clinical investigation. 2011 121:2169-80. [PubMed:21606596] [PMC:PMC3104757] Related Antibodies: LS-B2293.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).