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IFT57 / HIPPI
intraflagellar transport 57 homolog (Chlamydomonas)
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway By similarity. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
| Gene Name: | intraflagellar transport 57 homolog (Chlamydomonas) |
| Synonyms: | IFT57, MHS4R2, HIP1-interacting protein, DERP8, ESRRBL1, HIP1 protein interactor, HIPPI |
| Target Sequences: | AF245220 AAK28373.1 Q9NWB7 |
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