IFNL2 / IL28A

interferon, lambda 2

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

IFNL2 / IL28A (9)

Publications

No (9)

Tag

6His, C-terminus (2)

His (1)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (2)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (1)

Human Cells (1)

Mammalian Cells (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (4)

Biologically Active

Biologically active (2)

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IFNL2 / IL28A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105581

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.1 kDa

Price:

100 µg/$494

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Human IFNL2 / IL28A Protein (Recombinant His, N-Terminal) - LS-G144410

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

22.1 kDa

Price:

50 µg/$419

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Human IFNL2 / IL28A Protein (Recombinant His) - LS-G2779

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human IFNL2 / IL28A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93074

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.1 kDa

Price:

20 µg/$150

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Human IFNL2 / IL28A Protein (Recombinant) - LS-G249

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

19.6 kDa

Price:

5 µg/$268; 20 µg/$349

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Mouse IFNL2 / IL28A Protein (Recombinant) - LS-G240

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

19.8 kDa

Price:

5 µg/$268; 20 µg/$349

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Human IFNL2 / IL28A Protein (Recombinant 6His, C-terminus) (Val26-Val200) - LS-G139612

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.6 kDa

Price:

10 µg/$288; 50 µg/$436

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Human IFNL2 / IL28A Protein (Recombinant 6His, C-terminus) (Val26-Val200) - LS-G40360

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.6kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,377; 1 mg/$1,765

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Human IFNL2 / IL28A Protein (Recombinant His-GST) (aa26-200) - LS-G14147

Source:

E. coli

Tag:

His-GST

Molecular Weight:

52.1 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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