IFIT3

interferon-induced protein with tetratricopeptide repeats 3

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

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Products

Antibodies (29)

Proteins (10)

Type

Over-Expression Lysate (4)

Primary (29)

Recombinant (6)

Target

IFIT3 (39)

Reactivity

Human (28)

Mouse (3)

Rat (2)

Application

IHC (11)

IHC-P (9)

WB (22)

Flo (2)

ELISA (8)

ICC (1)

IF (2)

IP (4)

Peptide-ELISA (1)

Host

rabbit (25)

mouse (4)

Product Group

IHCPlus (1)

Isotype

IgG (25)

IgG1 (2)

IgG1,k (1)

Clonality

monoclonal mc (3)

polyclonal pc (26)

Clone

2C10 (1)

OTI1G1 (2)

Format

APC Conjugated (1)

Biotin Conjugated (3)

Carrier-free (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (18)

Epitope

aa1-490 (4)

aa51-100 (4)

aa230-490 (1)

aa325-375 (1)

aa350-400 (1)

Publications

No (39)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-SUMO (1)

Myc-DDK (Flag) (6)

Species

Human (8)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (2)

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IFIT3 Antibody (aa51-100) LS-C80794

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa51-100) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$424

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IFIT3 Antibody (aa51-100, HRP) LS-C448326

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa51-100) (HRP) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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IFIT3 Antibody (aa51-100, Biotin) LS-C448303

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa51-100) (Biotin) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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IFIT3 Antibody (aa51-100, FITC) LS-C448304

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa51-100) (FITC) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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IHC-plus™ IFIT3 Antibody (aa1-490) LS-B15237

(4.0) Rating

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa1-490) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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IFIT3 Antibody (aa1-490, HRP) LS-C369810

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa1-490) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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IFIT3 Antibody (aa1-490, Biotin) LS-C369811

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa1-490) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

IFIT3 Antibody (aa1-490, FITC) LS-C369808

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa1-490) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

IFIT3 Antibody (aa230-490) LS-C186265

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa230-490) Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

Select

IFIT3 Antibody (clone 2C10) LS-C197493

Antibody:

IFIT3 Mouse anti-Human Monoclonal (2C10) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µg/$423

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IFIT3 Antibody (clone OTI1G1) LS-C114808

Antibody:

IFIT3 Mouse anti-Human Monoclonal (OTI1G1) Antibody

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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IFIT3 Antibody (clone OTI1G1, Carrier-free) LS-C784443

Antibody:

IFIT3 Mouse anti-Human Monoclonal (Carrier-free) (OTI1G1) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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Human IFIT3 Protein (Recombinant His) - LS-G3325

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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IFIT3 Antibody LS-C336159

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

Select

IFIT3 Antibody LS-C753027

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$351

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IFIT3 Antibody LS-C767404

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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IFIT3 Antibody LS-C778428

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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IFIT3 Antibody LS-C310703

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$749

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IFIT3 Antibody LS-C807494

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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IFIT3 Antibody LS-C749018

Antibody:

IFIT3 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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IFIT3 Antibody LS-C310706

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

IFIT3 Antibody LS-C748372

Antibody:

IFIT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

IFIT3 Antibody (aa325-375) LS-C762713

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa325-375) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

IFIT3 Antibody (aa350-400) LS-C762715

Antibody:

IFIT3 Rabbit anti-Human Polyclonal (aa350-400) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

IFIT3 Antibody LS-C308385

Antibody:

IFIT3 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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