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IDS / Iduronate 2 Sulfatase

iduronate 2-sulfatase

Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described.

Gene Name:	iduronate 2-sulfatase
Synonyms:	IDS, SIDS, Iduronate 2-sulfatase, MPS2
Target Sequences:	NM_000202 NP_000193.1 P22304

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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