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IDN3 / NIPBL

Nipped-B homolog (Drosophila)

IDN3 / NIPBL is the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: Nipped-B homolog (Drosophila)
Synonyms: NIPBL, CDLS1, CDLS, Delangin, IDN3, Nipped-B homolog (Drosophila), IDN3-B, Scc2, SCC2 homolog, Nipped-B-like protein
Target Sequences: NM_015384 NP_056199.2 Q6KC79

Publications (1)

1
The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends. Gelot C, Guirouilh-Barbat J, Le Guen T, Dardillac E, Chailleux C, Canitrot Y, Lopez BS. Molecular cell. 2016 61:15-26. (WB, IP; Human) [Full Text Article] [PubMed:26687679]

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IDN3 / NIPBL (2)
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IDN3 / NIPBL Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
IDN3 / NIPBL Protein - 12.5% SDS-PAGE of human NIPBL stained with Coomassie Blue
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Wheat Germ Extract
GST
45.9 kDa
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).