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ICSBP / IRF8
interferon regulatory factor 8
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
| Gene Name: | interferon regulatory factor 8 |
| Synonyms: | IRF8, H-ICSBP, Interferon regulatory factor 8, ICSBP, ICSBP1, IRF-8 |
| Target Sequences: | NM_002163 NP_002154.1 Q02556 |
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