ICOS / CD278

inducible T-cell co-stimulator

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

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Products

Proteins (26)

Type

Recombinant (26)

Target

ICOS / CD278 (26)

Format

Preservative Free (1)

Publications

No (26)

Tag

6His, C-terminus (2)

6His, N-terminus (1)

Fc (1)

Fc, C-terminus (4)

Fc-His, C-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His-Fc (1)

His-GST (1)

Human IgG1 Fc (1)

Human Mutant IgG1 Fc (1)

Mouse IgG2 Fc (2)

more less

Species

Human (16)

Monkey-Rhesus (1)

Mouse (6)

Rat (3)

Source

CHO Cells (11)

E. coli (4)

HEK 293 Cells (2)

Human Cells (4)

Mammalian Cells (3)

Wheat Germ Extract (2)

Purification

Purified (9)

Low Endotoxin Level

Low endotoxin level (14)

Biologically Active

Biologically active (3)

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Human ICOS / CD278 Protein (Recombinant His-GST) (aa31-190) - LS-G12784

Source:

E. coli

Tag:

His-GST

Molecular Weight:

50.1 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human ICOS / CD278 Protein (Recombinant Mouse IgG2 Fc) (aa21-139) - LS-G4071

Source:

CHO Cells

Tag:

Mouse IgG2 Fc

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

100 µg/$463

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Mouse ICOS / CD278 Protein (Recombinant His) (aa35-131) - LS-G12787

Source:

E. coli

Tag:

His

Molecular Weight:

12.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ICOS / CD278 Protein (Recombinant Human IgG1 Fc) (aa21-139) - LS-G4054

Source:

CHO Cells

Tag:

Human IgG1 Fc

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

100 µg/$449

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Mouse ICOS / CD278 Protein (Recombinant 6His, C-terminus) (Glu21-Leu142) - LS-G40371

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.7kD

Price:

10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113

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Human ICOS / CD278 Protein (Recombinant GST, N-terminus) (aa21-140) - LS-G62308

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ICOS / CD278 Protein (Recombinant Fc, C-terminus) (Glu21-Phe141) - LS-G39389

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.8kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Rat ICOS / CD278 Protein (Recombinant 6His, N-terminus) (aa21-145) - LS-G56991

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human ICOS / CD278 Protein (Recombinant His-Fc) (Met1-Phe141) - LS-G97559

Source:

Human Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

41.6 kDa

Price:

100 µg/$721

Select

Rat ICOS / CD278 Protein (Recombinant His) (aa39-133) - LS-G12789

Source:

E. coli

Tag:

His

Molecular Weight:

12.2 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human ICOS / CD278 Protein (Recombinant GST) (Full Length) - LS-G33440

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.22 kDa

Price:

2 µg/$439

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Mouse ICOS / CD278 Protein (Recombinant) - LS-G137595

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

The 360 amino acid recombinant protein with a C-terminal human IgG1 Fc tag has a predicted molecular mass of approximately 44 kD. The protein migrates as above 60 kD in SDS-PAGE in DTT-reducing condition and above 110 kD in non-reducing condition. The N-t

Price:

25 µg/$322; 100 µg/$451

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Human ICOS / CD278 Protein (Recombinant) - LS-G137596

Source:

CHO Cells

Tag:

None

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

The 359 amino acid recombinant protein with a C-terminal human IgG1 Fc tag has a predicted molecular mass of approximately 44 kD. The protein migrates above 60 kD in SDS-PAGE in DTT-reducing condition and above 120 kD in non-reducing condition. The N-term

Price:

10 µg/$272; 25 µg/$306; 100 µg/$436

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Mouse ICOS / CD278 Protein (Recombinant Fc, C-terminus) (Met1-Leu142) - LS-G138509

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.9 kDa

Price:

100 µg/$793; 1 mg/$4,191

Select

Human ICOS / CD278 Protein (Recombinant Fc, C-terminus) (Glu21-Phe141) - LS-G139352

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.8 kDa

Price:

10 µg/$281; 50 µg/$389

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Monkey-Rhesus ICOS / CD278 Protein (Recombinant Fc, C-terminus) (Gly20-Lys140) - LS-G139410

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

40.8 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Human ICOS / CD278 Protein (Recombinant) - LS-G133820

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

79.4 kDa or 40-45 kDa

Price:

10 µg/$268; 50 µg/$349

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Human ICOS / CD278 Protein (Recombinant) (Biotin) - LS-G136266

Source:

CHO Cells

Tag:

None

Molecular Weight:

42.8 kDa

Price:

25 µg/$780

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Human ICOS / CD278 Protein (Recombinant) - LS-G136269

Source:

CHO Cells

Tag:

None

Molecular Weight:

42.8 kDa

Price:

25 µg/$575

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Human ICOS / CD278 Protein (Recombinant) - LS-G136270

Source:

CHO Cells

Tag:

None

Molecular Weight:

42.8 kDa

Price:

25 µg/$575

• Unmodified
• Preservative Free

• Unmodified
• Preservative Free

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Human ICOS / CD278 Protein (Recombinant) (Phycoerythrin) - LS-G136278

Source:

CHO Cells

Tag:

None

Price:

50 Tests/$985

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Mouse ICOS / CD278 Protein (Recombinant 6His, C-terminus) (Glu21-Leu142) - LS-G138596

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14.7 kDa

Price:

10 µg/$233; 50 µg/$277

Select

Human ICOS / CD278 Protein (Recombinant Fc-His, C-terminus) - LS-G142265

Source:

HEK 293 Cells

Tag:

Fc-His, C-terminus

Molecular Weight:

39 kDa

Price:

20 µg/$1,107

Select

Human ICOS / CD278 Protein (Recombinant Human Mutant IgG1 Fc) (aa21-139) - LS-G4091

Source:

CHO Cells

Tag:

Human Mutant IgG1 Fc

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

100 µg/$463

Select

Mouse ICOS / CD278 Protein (Recombinant Mouse IgG2 Fc) (aa21-142) - LS-G4130

Source:

CHO Cells

Tag:

Mouse IgG2 Fc

Endotoxin Level:

Less than 0.06 EU/µg protein (determined by LAL method).

Price:

100 µg/$463

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