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ICAM4 / CD242
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICAM4 / CD242 is the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Gene Name: | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) |
| Family/Subfamily: | ICAM , not assigned-ICAM |
| Synonyms: | ICAM4, CD242 antigen, LW, LW blood group protein, ICAM-4, CD242, Landsteiner-Wiener blood group |
| Target Sequences: | NM_001544 NP_001535.1 Q14773 |
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