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20700 44th Avenue W
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IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Gene Name: | inhibitor of Bruton agammaglobulinemia tyrosine kinase |
| Synonyms: | IBTK, BTBD26, BTKI, BTK-binding protein, KIAA1417, RP1-93K22.1, DKFZP564B116 |
| Target Sequences: | AL050018 CAB43239.1 Q9P2D0 |
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