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IAPP / Amylin

islet amyloid polypeptide

IAPP / Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity.

Gene Name: islet amyloid polypeptide
Synonyms: IAPP, Diabetes-associated peptide, Islet amyloid polypeptide, AMYLIN, IAP, Insulinoma amyloid peptide
Target Sequences: NM_000415 NP_000406.1 P10997

Publications (6)

1
Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Journal of the American Heart Association. 2014 3: (WB; Human) [Full Text Article] [PubMed:25146704] [PMC:PMC4310392] Related Antibodies: LS-C20521.
2
Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation. Ribeiro D, Horvath I, Heath N, Hicks R, Forslöw A, Wittung-Stafshede P. Proceedings of the National Academy of Sciences of the United States of America. 2017 October;114:11127-11132. [Full Text Article] [PubMed:28973954] [PMC:PMC5651775]
3
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Pietro Sormanni, Francesco A Aprile, Michele Vendruscolo. Proceedings of the National Academy of Sciences of the United States of America. 2015 August;112:9902-7. [Full Text Article] [PubMed:26216991] [PMC:PMC4538631] Related Antibodies: LS-B35.
4
Melatonin influences the expression and oligomerization of amylin in rat INS-1E cells. E-M Jung, Y-M Yoo, E-B Jeung. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 October;70: [Full Text Article] [PubMed:31889041] Related Antibodies: LS-C352341.
5
Human Islet Amyloid Polypeptide Overexpression in INS-1E Cells Influences Amylin Oligomerization under ER Stress and Oxidative Stress. Yeong-Min Yoo, Seong Soo Joo. International journal of molecular sciences. 2021 Oct;22:11341. [Full Text Article] [PubMed:34768769] [PMC:PMC8583535] Related Antibodies: LS-C352341.
6
Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Jackson K, Barisone GA, Diaz E, Jin LW, DeCarli C, Despa F. Annals of neurology. 2013 Oct;74:517-26. [Full Text Article] [PubMed:23794448] [PMC:PMC3818462] Related Antibodies: LS-C20521.
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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
IAPP / Amylin (6)
No (6)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
IAPP / Amylin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
IAPP / Amylin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
9.81 kDa
20 µg/$150
IAPP / Amylin Protein - 12.5% SDS-PAGE of human IAPP stained with Coomassie Blue
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Wheat Germ Extract
GST
36.2 kDa
2 µg/$439
IAPP / Amylin Protein - Purified recombinant protein IAPP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
3.9 kDa
20 µg/$1,107
IAPP / Amylin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
9.81 kDa
100 µg/$494
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E. coli
88 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
9.79 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).