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IAPP / Amylin

islet amyloid polypeptide

IAPP / Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity.

Gene Name: islet amyloid polypeptide
Synonyms: IAPP, Diabetes-associated peptide, Islet amyloid polypeptide, AMYLIN, IAP, Insulinoma amyloid peptide
Target Sequences: NM_000415 NP_000406.1 P10997

Publications (6)

1
Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Journal of the American Heart Association. 2014 3: (WB; Human) [Full Text Article] [PubMed:25146704] [PMC:PMC4310392] Related Antibodies: LS-C20521.
2
Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation. Ribeiro D, Horvath I, Heath N, Hicks R, Forslöw A, Wittung-Stafshede P. Proceedings of the National Academy of Sciences of the United States of America. 2017 October;114:11127-11132. [Full Text Article] [PubMed:28973954] [PMC:PMC5651775]
3
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Pietro Sormanni, Francesco A Aprile, Michele Vendruscolo. Proceedings of the National Academy of Sciences of the United States of America. 2015 August;112:9902-7. [Full Text Article] [PubMed:26216991] [PMC:PMC4538631] Related Antibodies: LS-B35.
4
Melatonin influences the expression and oligomerization of amylin in rat INS-1E cells. E-M Jung, Y-M Yoo, E-B Jeung. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 October;70: [Full Text Article] [PubMed:31889041] Related Antibodies: LS-C352341.
5
Human Islet Amyloid Polypeptide Overexpression in INS-1E Cells Influences Amylin Oligomerization under ER Stress and Oxidative Stress. Yeong-Min Yoo, Seong Soo Joo. International journal of molecular sciences. 2021 Oct;22:11341. [Full Text Article] [PubMed:34768769] [PMC:PMC8583535] Related Antibodies: LS-C352341.
6
Amylin deposition in the brain: A second amyloid in Alzheimer disease?. Jackson K, Barisone GA, Diaz E, Jin LW, DeCarli C, Despa F. Annals of neurology. 2013 Oct;74:517-26. [Full Text Article] [PubMed:23794448] [PMC:PMC3818462] Related Antibodies: LS-C20521.
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ELISA Kits (24)
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IAPP / Amylin (24)
Human (8)
Mouse (7)
Rat (4)
Chicken (1)
Dog (1)
Monkey (1)
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IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$782
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
6.17 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Chicken
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rabbit
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
IAPP / Amylin ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
IAPP / Amylin ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
IAPP / Amylin ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$929
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
7.813 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
47 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$1,041
IAPP / Amylin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
25 - 1600 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$1,081
IAPP / Amylin ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
IAPP / Amylin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).