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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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HTR1A / 5-HT1A Receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
| Gene Name: | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled |
| Family/Subfamily: | GPCR , Serotonin |
| Synonyms: | HTR1A, 5-HT-1A, 5HT1a, 5-HT1a receptor, 5HT1ar, 5HT1A receptor, 5-HT1A, ADRBRL1, ADRB2RL1, PFMCD, Serotonin 5-HT-1a receptor, Serotonin type 1a receptor, Serotonergic type 1A receptor, G-21, Serotonin 1a receptor, Serotonin receptor 1A |
| Target Sequences: | NM_000524 NP_000515.2 P08908 |
Publications (2)
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