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HT2A / TRIM32

tripartite motif containing 32

Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Gene Name: tripartite motif containing 32
Family/Subfamily: Tripartite Motif
Synonyms: TRIM32, 72 kDa Tat-interacting protein, HT2A, LGMD2H, TATIP, Tripartite motif containing 32, Zinc finger protein HT2A, Zinc-finger protein HT2A, TAT-interactive protein, 72-KD, BBS11, Tripartite motif-containing 32
Target Sequences: NM_012210 NP_036342.2 Q13049

Publications (1)

1
Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Kudryashova E, Wu J, Havton LA, Spencer MJ. Human molecular genetics. 2009 18:1353-67. (WB; Mouse) [Full Text Article] [PubMed:19155210] [PMC:PMC2722196] Related Antibodies: LS-B1105.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).