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HSPD1 / HSP60

heat shock 60kDa protein 1 (chaperonin)

HSPD1 / HSP60 is a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

Gene Name: heat shock 60kDa protein 1 (chaperonin)
Synonyms: HSPD1, 60 kDa chaperonin, CPN60, Heat shock protein 65, Heat shock protein 60, HSP-60, HSP60, HuCHA60, HLD4, HSP65, p60 lymphocyte protein, SPG13, Chaperonin 60, GROEL
Target Sequences: NM_002156 NP_002147.2 P10809

Publications (3)

1
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Burstein SR, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, Milner TA, Cloonan SM, Lutz C, Barrientos A, Manfredi G. Human molecular genetics. 2018 January;27:160-177. [Full Text Article] [PubMed:29112723] [PMC:PMC5886281] Related Antibodies: LS-B2040.
2
Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis. Alba Timón-Gómez, Joshua Garlich, Rosemary A Stuart, Cristina Ugalde, Antoni Barrientos. Cell reports. 2020 May;31:107607. [Full Text Article] [PubMed:32375044] Related Antibodies: LS-B2040.
3
Belantamab Mafodotin (GSK2857916) Drives Immunogenic Cell Death and Immune-mediated Antitumor Responses In Vivo10<sup> Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden12<sup> Oncology R&D, GlaxoSmithKline, Collegeville, Pennsylvania. Rocio Montes de Oca, Alireza S Alavi, Nick Vitali, Sabyasachi Bhattacharya, Christina Blackwell, Krupa Patel, Laura Seestaller-Wehr, Heather Kaczynski, Hong Shi, Eric Dobrzynski, Leslie Obert, Lyuben Tsvetkov, David C Cooper, Heather Jackson, Paul Bojczuk, Sabrina Forveille , Oliver Kepp , Allan Sauvat , Guido Kroemer , Mark Creighton-Gutteridge, Jingsong Yang, Chris Hopson, Niranjan Yanamandra, Christopher Shelton, Patrick Mayes, Joanna Opalinska, Mary Barnette, Roopa Srinivasan, James Smoth. The Breast : official journal of the European Society of Mastology. 2021 Oct;;20:1941-1955. [Full Text Article] [PubMed:34253590]

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Proteins (19)
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HSPD1 / HSP60 (19)
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His-T7 (2)
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293T Cells (2)
E. coli (12)
HEK 293 Cells (4)
Wheat Germ Extract (1)
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HSPD1 / HSP60 Protein
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Human HSPD1 / HSP60 Protein (Recombinant His) - LS-G3458
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
HSPD1 / HSP60 Protein
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Human HSPD1 / HSP60 Protein (Recombinant His, N-Terminal) - LS-G144154
E. coli
His, N-Terminal
60.9 kDa
50 µg/$419
HSPD1 / HSP60 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human HSPD1 / HSP60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77391
293T Cells
Myc-DDK (Flag)
60.9 kDa
20 µg/$150
HSPD1 / HSP60 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human HSPD1 / HSP60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77392
293T Cells
Myc-DDK (Flag)
60.9 kDa
20 µg/$150
HSPD1 / HSP60 Protein
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Human HSPD1 / HSP60 Protein (Recombinant His, N-Terminal) (Ala27-Phe573) - LS-G96867
E. coli
His, N-Terminal
58 kDa
10 µg/$265; 200 µg/$484; 50 µg/$315
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Human HSPD1 / HSP60 Protein (Over-Expression Lysate His, N-Terminal) (Ala27-Phe573) - LS-G96869
HEK 293 Cells
His, N-Terminal
~58 kDa
100 µg/$298
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Human HSPD1 / HSP60 Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (Ala27-Phe573) - LS-G96871
HEK 293 Cells
His, N-Terminal
~58 kDa
200 µl/$283
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Human HSPD1 / HSP60 Protein (Recombinant His-GST) (Leu2-Phe573) - LS-G97546
E. coli
His-GST
88.7 kDa
100 µg/$721
HSPD1 / HSP60 Protein - Recombinant Heat Shock 60kD Protein 1, Chaperonin By SDS-PAGE
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Human HSPD1 / HSP60 Protein (Recombinant His) (aa172-343) - LS-G12933
E. coli
His
19.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
HSPD1 / HSP60 Protein - Recombinant Heat Shock 60kD Protein 1, Chaperonin By SDS-PAGE
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Mouse HSPD1 / HSP60 Protein (Recombinant His-T7) (aa28-573) - LS-G12936
E. coli
His-T7
61.4 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
HSPD1 / HSP60 Protein - Recombinant Heat Shock 60kD Protein 1, Chaperonin By SDS-PAGE
Select
Mouse HSPD1 / HSP60 Protein (Recombinant His-T7) (aa316-573) - LS-G12937
E. coli
His-T7
30.6 kDa
10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
HSPD1 / HSP60 Protein - Recombinant Heat Shock 60kD Protein 1, Chaperonin By SDS-PAGE
Select
Human HSPD1 / HSP60 Protein (Recombinant His) (aa1-573) - LS-G12927
E. coli
His
62.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
HSPD1 / HSP60 Protein - 12.5% SDS-PAGE of human HSPD1 stained with Coomassie Blue
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Human HSPD1 / HSP60 Protein (Recombinant GST) (Full Length) - LS-G28942
Wheat Germ Extract
GST
88.77 kDa
10 µg/$479; 25 µg/$670
HSPD1 / HSP60 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HSPD1 / HSP60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99667
HEK 293 Cells
Myc-DDK (Flag)
60.9 kDa
100 µg/$494
HSPD1 / HSP60 Protein - SDS-PAGE of 60kDa Hsp60 protein.
Select
Human HSPD1 / HSP60 Protein (Recombinant His) - LS-G141255
E. coli
His
50 µg/$344; 100 µg/$470
Select
Human HSPD1 / HSP60 Protein - LS-G134043
E. coli
None
63 kDa
5 µg/$329; 20 µg/$412; 1000 µg/$3,417
HSPD1 / HSP60 Protein
Select
Human HSPD1 / HSP60 Protein (Recombinant His) - LS-G2254
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
Select
Mouse HSPD1 / HSP60 Protein (Recombinant His) (Leu2-Phe573) - LS-G98175
E. coli
His
62.3 kDa
100 µg/$721
HSPD1 / HSP60 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HSPD1 / HSP60 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103334
HEK 293 Cells
Myc-DDK (Flag)
60.9 kDa
100 µg/$494
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