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HSPA5 / GRP78 / BiP

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate.

Gene Name: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Synonyms: HSPA5, BIP, Heat shock 70 kDa protein 5, MIF2, GRP-78, GRP78
Target Sequences: M19645 AAA52614.1 P11021

Publications (9)

1
NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ. American journal of physiology. Endocrinology and metabolism. 2013 304:E392-404. (WB; Mouse) [PubMed:23233541] [PMC:PMC3566505]
2
Cell-extrinsic effects of tumor ER stress imprint myeloid dendritic cells and impair CD8 T cell priming. Mahadevan NR, Anufreichik V, Rodvold JJ, Chiu KT, Sepulveda H, Zanetti M. PloS one. 2012 7:e51845. [PubMed:23272178] [PMC:PMC3525659] Related Antibodies: LS-C165064.
3
Proteomic analysis of solid pseudopapillary tumor of the pancreas reveals dysfunction of the endoplasmic reticulum protein processing pathway. Zhu Y, Xu H, Chen H, Xie J, Shi M, Shen B, Deng X, Liu C, Zhan X, Peng C. Molecular & cellular proteomics : MCP. 2014 13:2593-603. (WB; Human, Rat) [Full Text Article] [PubMed:24997997] [PMC:PMC4188989]
4
Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?. Van Hoesen K, Meynier S, Ribaux P, Petignat P, Delie F, Cohen M. Oncotarget. 2017 November;8:107176-107187. (Human) [Full Text Article] [PubMed:29291021] [PMC:PMC5739806] Related Antibodies: LS-C165063.
5
BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway. Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR. BMC cancer. 2018 April;18:412. (Human) [Full Text Article] [PubMed:29649984] [PMC:PMC5898062] Related Antibodies: LS-C312961.
6
Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia. Haimei Qin, Rong Wang, Xiaoxia Pang, Yuxiao Wei, Fenglian Yang, Junli Wang. Journal of assisted reproduction and genetics. 2018 December;35:2223-2231. [Full Text Article] [PubMed:30229503] [PMC:PMC6289912]
7
Auxiliary proteins that facilitate formation of collagen-rich deposits in the posterior knee capsule in a rabbit-based joint contracture model. Andrzej Steplewski, Jolanta Fertala, Pedro K Beredjiklian , Joseph A Abboud , Mark L Y Wang , Surena Namdari , Jonathan Barlow , Michael Rivlin , William V Arnold , James Kostas, Cheryl Hou, Andrzej Fertala. The Breast : official journal of the European Society of Mastology. 2016 Mar;;34:489-501. [Full Text Article] [PubMed:26241613] Related Antibodies: LS-B4157.
8
Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease. Yeawon Kim, Zheyu Wang, Chuang Li, Kendrah Kidd, Yixuan Wang, Bryce G Johnson, Stanislav Kmoch, Jeremiah J Morrissey, Anthony J Bleyer, Jeremy S Duffield, Srikanth Singamaneni, Ying Maggie Chen. American journal of physiology. Renal physiology. 2021 July;321:F236-F244. [Full Text Article] [PubMed:34251273] [PMC:PMC8424663] Related Antibodies: LS-B2038.
9
Endoplasmic reticulum-resident chaperones modulate the inflammatory and angiogenic responses of endothelial cells. R Tsaryk, N M Bartholomä, N Simiantonaki, L Anspach, K Peters, C Heilmann, C J Kirkpatrick, F Pröls. The British journal of dermatology. 2015 August;173:416-27. [Full Text Article] [PubMed:25832777] Related Antibodies: LS-B4157.
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Antibodies (167)
Primary (167)
HSPA5 / GRP78 / BiP (167)
Human (139)
Mouse (109)
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IHC (64)
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WB (162)
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rabbit (103)
mouse (58)
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1672CT323.22.82 (1)
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No (162)
Yes (5)
HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa550-600) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
HSPA5 / GRP78 / BiP Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 / BIP antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Monoclonal (Gly584) Antibody
Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$565
HSPA5 / GRP78 / BiP Antibody - HSPA5 / GRP78 / BIP antibody. IHC(P): Rat Intestine Tissue.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa603-617) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
HSPA5 / GRP78 / BiP Antibody - HSPA5 Antibody IHC of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa261-289) Antibody
Zebrafish, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
400 µl/$393
HSPA5 / GRP78 / BiP Antibody - HSPA5 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa541-568) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
HSPA5 / GRP78 / BiP Antibody - Western blot of COS7 cell lysate using GRP78 Antibody
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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HSPA5 / GRP78 / BiP Mouse anti-Rat Monoclonal (aa649-654) (10C3) Antibody
Rat, Yeast
ELISA, ICC, IHC, IP, WB
Unconjugated
50 µg/$582
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal (RPE) (6H4.2G7) Antibody
Human
ELISA, WB
RPE Conjugated
100 µg/$451
HSPA5 / GRP78 / BiP Antibody - Anti-HSPA5 / GRP78 / BIP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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HSPA5 / GRP78 / BiP Rabbit anti-Rat Polyclonal (aa645-654) Antibody
Xenopus, Fungus, Rat, Hamster, Rabbit, Mouse, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (FITC) Antibody
Xenopus, Cryphonectria parasitica, Rat, Hamster, Rabbit, Mouse, Dog, Bovine, Human, Monkey
ICC, IHC, WB
FITC Conjugated
200 µl/$509
HSPA5 / GRP78 / BiP Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Goat anti-Human Polyclonal Antibody
Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
HSPA5 / GRP78 / BiP Antibody - Immunohistochemical analysis of paraffin-embedded Colorectal cancer using BiP/GRP78 (C-terminus) mouse monoclonal antibody (1:100 dilution).Antigen retrieval was performed by pressure cooking in citrate buffer (pH 6.0).
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$391
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HSPA5 / GRP78 / BiP Rat anti-Mouse Monoclonal (aa497-581) Antibody
Mouse
ELISA, WB
Unconjugated
500 µg/$577
HSPA5 / GRP78 / BiP Antibody - Use at 0.5-1.0ug/ml. A band of ~78kDa is detected.
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal (6H4-2G7) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$453
HSPA5 / GRP78 / BiP Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$460
HSPA5 / GRP78 / BiP Antibody - Human Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$460
HSPA5 / GRP78 / BiP Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa261-289) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
HSPA5 / GRP78 / BiP Antibody - Western blot of GRP78 Antibody with human 293T Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Mouse, Goat, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human
WB
Biotin Conjugated
100 µl/$469
HSPA5 / GRP78 / BiP Antibody - The cell lysates of HeLa and MCF7 (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BIP antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal (AT3D2) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (aa541-568) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
HSPA5 / GRP78 / BiP Antibody - HSPA5 / GRP78 / BiP antibody immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (5ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
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HSPA5 / GRP78 / BiP Goat anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
HSPA5 / GRP78 / BiP Antibody - Western blot analysis of GRP78 in Glia GD cell lysates using a 1:1000 dilution of HSPA5 / GRP78 / BIP antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSPA5 / GRP78 / BiP Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Dog, Rat, Human
ELISA, IHC, WB
Biotin Conjugated
100 µg/$455
HSPA5 / GRP78 / BiP Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSPA5 / GRP78 / BiP Mouse anti-Human Monoclonal (1672CT323.22.82) Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
100 µl/$460
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).