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In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
Gene Name: | heat shock 70kDa protein 2 |
Synonyms: | HSPA2, Heat shock 70kD protein 2, HSP70-2, HSP70-3, Heat shock 70 kDa protein 2, Heat shock 70kDa protein 2 |
Target Sequences: | NM_021979 NP_068814.2 P54652 |
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