HSD2 / HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

HSD2 / HSD11B2 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Rat (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

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Human HSD2 / HSD11B2 Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G22957

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

46.1 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human HSD2 / HSD11B2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65308

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$1,107

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HSD2 / HSD11B2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123339

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

100 µg/$494

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Human HSD2 / HSD11B2 Protein (Recombinant GST, N-terminus) (aa71-170) - LS-G58901

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HSD2 / HSD11B2 Protein (Recombinant GST) (Full Length) - LS-G28926

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.5 kDa

Price:

2 µg/$439

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Rat HSD2 / HSD11B2 Protein (Recombinant His) (aa58-393) - LS-G25565

Source:

E. coli

Tag:

His

Molecular Weight:

40.5 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human HSD2 / HSD11B2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75314

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$150

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