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Lynnwood, WA 98036
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HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
| Gene Name: | hydroxysteroid (17-beta) dehydrogenase 6 |
| Synonyms: | HSD17B6, 17-beta-HSD6, 3-hydroxysteroid epimerase, 17-beta-HSD 6, HSE, Oxidoreductase, RODH, SDR9C6, Retinol dehydrogenase |
| Target Sequences: | NM_003725 NP_003716.2 O14756 |
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