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HSD11B1 / HSD11B

hydroxysteroid (11-beta) dehydrogenase 1

HSD11B1 / HSD11B is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Gene Name: hydroxysteroid (11-beta) dehydrogenase 1
Synonyms: HSD11B1, 11-beta-HSD1, 11-DH, CORTRD2, HSD11B, HSD11L, SDR26C1, HDL, HSD11
Target Sequences: NM_005525 NP_005516.1 P28845

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Products
Antibodies (47)
Primary (47)
HSD11B1 / HSD11B (47)
Human (36)
Mouse (18)
Rat (26)
Chimpanzee (1)
Dog (2)
Hamster (2)
Monkey (1)
Rabbit (2)
Sheep (3)
IHC (18)
IHC-Fr (2)
IHC-P (12)
WB (43)
ELISA (13)
ICC (2)
IF (1)
IP (2)
Peptide-ELISA (5)
rabbit (43)
mouse (2)
goat (2)
Product Group
IHCPlus (4)
IgG (28)
IgM,k (1)
monoclonal mc (1)
polyclonal pc (46)
2C10 (1)
APC (1)
APC Conjugated (2)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
Magnetic beads Conjugated (1)
PE Conjugated (2)
Sepharose Conjugated (1)
Unconjugated (30)
aa1-288 (8)
aa25-292 (6)
N-Terminus (4)
aa131-145 (3)
1-50 aa, N-terminal (1)
aa1-50 (1)
aa16-33 (1)
aa232-292 (1)
aa282-292 (1)
aa33-82 (1)
aa43-88 (1)
aa64-77 (1)
aa77-92 (1)
No (47)
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa131-145) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$380
HSD11B1 / HSD11B Antibody - Antibody (0.3 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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HSD11B1 / HSD11B Goat anti-Human Polyclonal (aa282-292) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
HSD11B1 / HSD11B Antibody - Anti-HSD11B1 / HSD11B antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa232-292) Antibody
Sheep, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$460
HSD11B1 / HSD11B Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
HSD11B1 / HSD11B Antibody - Anti-HSD11B1 antibody IHC of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa25-292) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
HSD11B1 / HSD11B Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa25-292) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa25-292) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa25-292) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa25-292) (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa131-145) (Sepharose) Antibody
Mouse, Rat, Human
IP
Sepharose Conjugated
100 µg/$399
HSD11B1 / HSD11B Antibody - Immunohistochemistry of 11beta-HSD1 antibody
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (1-50 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.
Select
HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa25-292) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
HSD11B1 / HSD11B Antibody - IHC analysis of HSD11B1 using anti-HSD11B1 antibody. HSD11B1 was detected in paraffin-embedded section of human lung cancer tissues. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-HSD11B1 Antibody overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC) with DAB as the chromogen.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa16-33) Antibody
Mouse, Rat, Chimpanzee, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
HSD11B1 / HSD11B Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using HSD11B1 antibody.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
HSD11B1 / HSD11B Antibody - HSD11B1 monoclonal antibody (M02A), clone 2C10. Western Blot analysis of HSD11B1 expression in human liver.
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HSD11B1 / HSD11B Mouse anti-Human Monoclonal (2C10) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$423
HSD11B1 / HSD11B Antibody - Western blot analysis of the lysates from HUVECcells using HSD11B1 antibody.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal (aa33-82) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
HSD11B1 / HSD11B Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Rat
ELISA, WB
Unconjugated
100 µl/$801
Select
HSD11B1 / HSD11B Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Rat
ELISA, WB
Unconjugated
100 µg/$832
HSD11B1 / HSD11B Antibody - Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue  using HSD11B1 Polyclonal Antibody at dilution of 1:70(×200)
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HSD11B1 / HSD11B Antibody - Western blot analysis of extracts of various cell lines.
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
HSD11B1 / HSD11B Antibody - HSD11B1 antibody (0.3 ug/ml) staining of Mouse Lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Select
HSD11B1 / HSD11B Goat anti-Mouse Polyclonal (aa64-77) Antibody
Mouse, Rat, Hamster
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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HSD11B1 / HSD11B Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Viewing 26-47 of 47 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).