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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HSD11B1 / HSD11B

hydroxysteroid (11-beta) dehydrogenase 1

HSD11B1 / HSD11B is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Gene Name: hydroxysteroid (11-beta) dehydrogenase 1
Synonyms: HSD11B1, 11-beta-HSD1, 11-DH, CORTRD2, HSD11B, HSD11L, SDR26C1, HDL, HSD11
Target Sequences: NM_005525 NP_005516.1 P28845

Filtered by: None
Target
HSD11B1 / HSD11B (49)
Reactivity
Human (36)
Mouse (17)
Rat (28)
Chimpanzee (1)
Dog (2)
Hamster (2)
Monkey (1)
Rabbit (2)
Sheep (3)
Application
IHC (26)
IHC-Fr (3)
IHC-P (13)
WB (46)
ELISA (12)
ICC (5)
IP (2)
Peptide-ELISA (4)
Host
rabbit (45)
mouse (2)
goat (2)
Isotype
IgG (27)
IgM,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (48)
Clone
2C10 (1)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Biotin Conjugated (4)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (3)
Magnetic beads Conjugated (1)
PE Conjugated (2)
Sepharose Conjugated (1)
Unconjugated (29)
Epitope
aa1-288 (10)
aa25-292 (6)
N-Terminus (4)
aa131-145 (4)
1-50 aa, N-terminal (1)
10-90 aa, N-terminal (1)
aa1-50 (1)
aa16-33 (1)
aa232-292 (1)
aa282-292 (1)
aa33-82 (1)
aa43-88 (1)
aa64-77 (1)
aa77-92 (1)
Publications
No (49)
Showing 1-25 of 49 results

HSD11B1 / HSD11B Antibody (aa77-92) IHC-plus™ LS-B1597
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Hamster, Human, Monkey
IHC IHC-P WB
Unconjugated
1ea  $425.00
Anti-HSD11B1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of HSD11B1 antibody.

HSD11B1 / HSD11B Antibody (aa131-145) LS-C172267
Rabbit Polyclonal to Human HSD11B1 / HSD11B
Mouse, Rat, Human
ICC IHC IHC-Fr IHC-P WB
Unconjugated
100µg 1mg/ml  $295.00

HSD11B1 / HSD11B Antibody (aa282-292) LS-C54982
Goat Polyclonal to Human HSD11B1 / HSD11B
Human
Peptide-ELISA WB
Unconjugated
100µg 0.5mg/ml  $405.00
Antibody (0.3 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

HSD11B1 / HSD11B Antibody (aa232-292) IHC-plus™ LS-B10496
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Sheep, Human
ICC IHC IHC-Fr IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-HSD11B1 / HSD11B antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HSD11B1 / HSD11B antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HSD11B1 / HSD11B Antibody (aa1-50) IHC-plus™ LS-B12532
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
100µl 1mg/ml  $505.00
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

HSD11B1 / HSD11B Antibody IHC-plus™ LS-B6547
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-HSD11B1 antibody IHC of human lung, macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

HSD11B1 / HSD11B Antibody (aa131-145, Sepharose) LS-C172269
Rabbit Polyclonal to Human HSD11B1 / HSD11B
Mouse, Rat, Human
IP
Sepharose Conjugated
100µg  $325.00

HSD11B1 / HSD11B Antibody (aa25-292) LS-C375929
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.

HSD11B1 / HSD11B Antibody (1-50 aa, N-terminal) LS-C387647
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemistry of 11beta-HSD1 antibody
Immunohistochemistry of 11beta-HSD1 antibody

HSD11B1 / HSD11B Antibody (aa131-145) LS-C388590
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Human
ICC IHC IHC-Fr IHC-P WB
Unconjugated
100µg  $435.00
IHC-P: HSD11B1 antibody testing of rat liver tissue
Western blot testing of HSD11B1 antibody and Lane 1: HeLa; 2: SMMC-7721; 3: Raji; 4: COLO320 cell lysate

HSD11B1 / HSD11B Antibody (aa25-292) LS-C369799
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Human
ELISA IHC IHC-P WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot. All lanes: Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody at 2 ug/ml+HeLa cells. Secondary antibody: goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HSD11B1 / HSD11B Antibody (aa25-292, HRP) LS-C369801
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Human
ELISA IHC IHC-P WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot. All lanes: Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody at 2 ug/ml+HeLa cells. Secondary antibody: goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HSD11B1 / HSD11B Antibody (aa25-292, Biotin) LS-C369802
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Human
ELISA IHC IHC-P WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot. All lanes: Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody at 2 ug/ml+HeLa cells. Secondary antibody: goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HSD11B1 / HSD11B Antibody (aa25-292, FITC) LS-C369797
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Human
ELISA IHC IHC-P WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot. All lanes: Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody at 2 ug/ml+HeLa cells. Secondary antibody: goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HSD11B1 / HSD11B Antibody (10-90 aa, N-terminal) LS-C381793
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of 11beta-HSD1 antibody
Western blot of 11beta-HSD1 antibody

HSD11B1 / HSD11B Antibody (aa33-82) LS-C292068
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Rat, Human
IHC Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of the lysates from HUVECcells using HSD11B1 antibody.

HSD11B1 / HSD11B Antibody (clone 2C10) LS-C197461
Mouse Monoclonal [clone 2C10] (IgM,k) to Human HSD11B1 / HSD11B
Human
ELISA WB
Unconjugated
200µl  $355.00
HSD11B1 monoclonal antibody (M02A), clone 2C10. Western Blot analysis of HSD11B1 expression in human liver.
HSD11B1 monoclonal antibody (M02A), clone 2C10. Western Blot analysis of HSD11B1 expression in MCF-7.

HSD11B1 / HSD11B Antibody (aa16-33) LS-C343882
Rabbit Polyclonal to Human HSD11B1 / HSD11B
Mouse, Rat, Chimpanzee, Human
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $355.00
HSD11B1 antibody Western blot. All lanes: All lanes: Anti HSD11B1 at 0.5 ug/ml. Lane 1: Rat Liver Tissue Lysate at 50 ug. Lane 2: Rat Testis Tissue Lysate at 50 ug. Lane 3: SMMC Whole Cell Lysate at 40 ug. Lane 4: RAJI Whole Cell Lysate at 40 ug. Lane 5: SW620 Whole Cell Lysate at 40 ug. Predicted band size: 32 kD. Observed band size: 32 kD.

HSD11B1 / HSD11B Antibody (aa25-292) LS-C375930
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Human
ELISA IHC IHC-P
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human liver using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human adrenal gland using antibody at 1:100 dilution.

HSD11B1 / HSD11B Antibody (N-Terminus) LS-C24604
Rabbit Polyclonal (IgG) to Mouse HSD11B1 / HSD11B
Mouse, Sheep, Rat
ELISA WB
Unconjugated
100µg  $755.00

HSD11B1 / HSD11B Antibody (N-Terminus) LS-C24603
Rabbit Polyclonal (IgG) to Mouse HSD11B1 / HSD11B
Mouse, Sheep, Rat
ELISA WB
Unconjugated
100µl  $725.00

HSD11B1 / HSD11B Antibody LS-C412479
Rabbit Polyclonal to Human HSD11B1 / HSD11B
Human
IHC WB
Unconjugated
100µl  $385.00

HSD11B1 / HSD11B Antibody LS-C335178
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Mouse, Human
IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of various cell lines.
Western blot analysis of extracts of mouse liver, using HSD11B1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.

HSD11B1 / HSD11B Antibody LS-C666224
Rabbit Polyclonal (IgG) to Human HSD11B1 / HSD11B
Human
ELISA WB
Unconjugated
100µg  $335.00

HSD11B1 / HSD11B Antibody (aa64-77) LS-C154869
Goat Polyclonal to Mouse HSD11B1 / HSD11B
Mouse, Rat, Hamster
Peptide-ELISA WB
Unconjugated
100µg 0.5mg/ml  $405.00
HSD11B1 antibody (0.3 ug/ml) staining of Mouse Lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
HSD11B1 antibody (0.3 ug/ml) staining of Mouse Lung lysate (60 ug protein in RIPA buffer). First lane shows wild type and second lane shows knockout background. Primary incubation was overnight. Detected by fluorescence with Li-cor). Data obtained from Prof. K. Chapman and Zhenguang Zhang, Centre for Cardiovascular Sciences, Queens Medical Research Institute, Edinburgh, UK
Showing 1-25 of 49 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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