HSBP1

heat shock factor binding protein 1

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

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Antibodies (14)

Proteins (6)

Type

Over-Expression Lysate (2)

Primary (14)

Recombinant (4)

Target

HSBP1 (20)

Reactivity

Human (14)

Mouse (5)

Rat (5)

Bat (3)

Bovine (4)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Horse (3)

Monkey (3)

Orangutan (3)

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Rabbit (3)

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Application

IHC (6)

IHC-P (4)

WB (14)

ELISA (7)

ICC (2)

IF (2)

Peptide-ELISA (1)

Host

rabbit (11)

mouse (2)

chicken (1)

Product Group

IHCPlus (1)

Isotype

IgG (10)

IgG1 (1)

IgG2a,k (1)

IgY (1)

Clonality

monoclonal mc (2)

polyclonal pc (12)

Clone

2C3 (1)

6H11 (1)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (8)

Epitope

N-Terminus (4)

aa1-76 (1)

Publications

No (20)

Tag

GST (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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HSBP1 Antibody (N-Terminus) LS-C101557

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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HSBP1 Antibody (N-Terminus, HRP) LS-C432924

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Rat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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HSBP1 Antibody (N-Terminus, Biotin) LS-C432922

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Rat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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HSBP1 Antibody (N-Terminus, FITC) LS-C432923

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Bovine, Bat, Rat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

HSBP1 Antibody (clone 6H11) LS-C204525

Antibody:

HSBP1 Mouse anti-Human Monoclonal (6H11) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$376

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IHC-plus™ HSBP1 Antibody LS-B12278

(4.0) Rating

Antibody:

HSBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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HSBP1 Antibody (HRP) LS-C316937

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

HSBP1 Antibody (Biotin) LS-C316939

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

HSBP1 Antibody (FITC) LS-C316938

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

HSBP1 Antibody LS-C666223

Antibody:

HSBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

HSBP1 Antibody (aa1-76) LS-C178580

Antibody:

HSBP1 Rabbit anti-Human Polyclonal (aa1-76) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$332

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HSBP1 Antibody LS-C204524

Antibody:

HSBP1 Chicken anti-Human Polyclonal Antibody

Reactivity:

Mouse, Bovine, Rat, Pig, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$376

Select

HSBP1 Antibody (clone 2C3) LS-C197459

Antibody:

HSBP1 Mouse anti-Human Monoclonal (2C3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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HSBP1 Antibody LS-C807490

Antibody:

HSBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human HSBP1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69484

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.4 kDa

Price:

20 µg/$1,107

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Human HSBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84757

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.4 kDa

Price:

20 µg/$150

Select

Human HSBP1 Protein (Recombinant GST) (Full Length) - LS-G22057

Source:

E. coli

Tag:

GST

Molecular Weight:

35.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human HSBP1 Protein (Recombinant GST) (Full Length) - LS-G28920

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

34.1 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human HSBP1 Protein (Recombinant) - LS-G3438

Source:

E. coli

Tag:

None

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

Select

HSBP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118520

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.4 kDa

Price:

100 µg/$494

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