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HS3ST1

heparan sulfate (glucosamine) 3-O-sulfotransferase 1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.

Gene Name:	heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms:	HS3ST1, 3OST1, 3-OST-1, 3OST, H3-OST-1
Target Sequences:	NM_005114 NP_005105.1 O14792

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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