HRS / HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

HRS / HGS (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human HRS / HGS Protein (Recombinant GST) (Full Length) - LS-G31499

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

112.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HRS / HGS Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67924

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

20 µg/$1,107

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Human HRS / HGS Protein (Recombinant GST, N-terminus) (aa513-612) - LS-G61010

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HRS / HGS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80991

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

20 µg/$150

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HRS / HGS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100372

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

100 µg/$494

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